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Synthesis and Structures of Organoselenium Compounds

Author: XuZuo
Tutor: WeiXueHong
School: Shanxi University
Course: Organic Chemistry
Keywords: Organic selenium compounds Synthesis Structure
CLC: R914
Type: Master's thesis
Year: 2008
Downloads: 321
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Abstract

Selenium is an important element of life for over 70 years, the chemical reaction of elemental selenium-depth research and extensive application. Physiological activity of organic selenium compounds caused a great interest of many scientists. Many selenides, selenium heterocyclic diselenide and selenium cyanide drugs have come out, and its potency launched a detailed study. Se drug development is organic selenium present and future chemical research hotspot, ebselen is an organic selenium drug development success story. The research is based on the above background, starting from the structure-activity relationships, the electrical, the spatial structure, on the synergy and selenium atoms with atomic-powered space adjacent remote effect on the ebselen and other selenium ethers, ethers diselenide its structure at the molecular level of the steric and electronic effects of the modification to improve, a new class of synthetic class ebselen diselenide compound and its structure, including the X-ray diffraction technology is fully characterized. The purpose is to obtain a high biological activity of organic selenium compounds, and further research in that field to provide strong theoretical support and research and development of new drugs to provide certain organic selenium technical support. Divided into the following main elements: The first chapter is an introduction, describes the research background of this thesis work mainly consists of three parts (1) Overview of selenium chemistry, mainly brief selenium in inorganic, organic, biochemical aspects of the development and application of ; (2) describes the types of organic selenium drugs, herbs, and the current research progress; (3) organic selenium drug development prospects. Different positions chapter II-substituted ebselen (ebselen) for the preparation of derivatives 2a-2e, and using NMR, elemental analysis, X-crystal diffraction by means of their structure and characteristics are characterized research. The third chapter of 2 - chloro-nicotinic acid as a starting material through the six-step reaction successfully synthesized pyrido selenazoyl TZDs 3a-3e, and the structure of these compounds were characterized. In addition, also for their crystal structure, and selenium and the adjacent nitrogen and oxygen atoms exist between nonbonding studied. Chapter IV through reagent 2 - chloro-nicotinic acid synthesis Out 2 - chloro-nicotinamide compounds after further with Na ₂ Se ₂ synthesized by the reaction of 2,2 '- two selenium and selenium ethers nicotinamide series two drugs 5a-5e, and their structures were characterized and some research. Chapter V, respectively, from two - chlorine selenium benzoyl chloride and 2 - chloro-benzene acid chloride starting selenium synthesis of some N-carbonyl and phenyl selenide trazodone carbonyl compounds and N-Se trazodone and pyridine ring new class of organic selenium compounds . Were characterized by their structure, while also part of the N-carbonyl group and phenyl selenide Trazodone made of the crystal structure. Summary and Outlook is part of the main contents of the thesis were to sum up, in the next phase of the work of outlook between the proposed method for the determination of potency.

Synthesis and Structures of Organoselenium Compounds

Abstract

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