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Purpose : the observed intestinal Feikangyin (CKY) role in the the UC rats efficacy and its mechanism . Methods: 70 healthy Wistar rats were randomly divided into six groups , group A : normal control group 10 , group B : model control group ( n = 12 ) , group C : CKY low- dose group, 12 group D : CKY dose group 12 only , E : CKY high dose group 12 , group F : SASP control group of 12 . A the group injected 0.25m10.9% saline enema , and the remaining five groups plus 50% ethanol 0.25ml mixed reagent enema injection of 100mg/kg TNBS . After modeling , the next day, C , D , E group CKY11g/kg 22g/kg and 44g/kg body weight orally F group at 0.5g/kg body weight orally , the A and B group were given distilled water, 10 ml of / kg body weight orally . Once daily gavage volume are 10mL/kg, for 21 consecutive days after the standard DAI score gross morphology scoring colonic tissue damage and histopathological score . Determination of colon tissue superoxide dismutase (SOD) activity and inducible nitric oxide synthase (iNOS) expression . Results: The rats DAI score , colon tissue damage by gross morphology score and histopathological score , intestinal tissue SOD activity and iNOS expression , E group compared with group B , a highly significant difference ( P <0.01 ) ; D , F group and group B, there is a significant difference ( P < 0.05 ) ; B , C group and A group comparison there is a very significant with difference ( P < 0.01 ) ; D , group F with A group comparison there is a significant difference ( P < 0.05 ) . Conclusion : CKY is an effective drug for the treatment of UC rat model . Effect than Group E Group F for the gifted . The CKY probably through enhanced intestinal tissue SOD activity and reduce the expression of iNOS therapeutic purposes .
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