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Purpose : the Lee the jaundice Kang particle treatment efficacy of drug-induced liver injury in endotoxin levels . Methods: Winstar rats were divided into normal control group , model control group , Lee jaundice Kang particles high in the low-dose group and Hugan Tablets group ( n = 12 ) . Normal control group was given a normal diet, normal drinking water , and not applied other anthropogenic factors . In addition to the normal control group , the rest of the group to take the first ANIT2g, heating dissolved in 100 ml of salad oil , the concentration of 2% W / V, spare . The modeling per rat per kg of body weight given ANIT100mg disposable gavage poisoning . High, medium and low- dose groups , respectively, according to 223.4mg / ( kg · d ) 111.7mg / (kg · d ) , the dose to 58.9mg / ( kg ) the Lee of jaundice Kang gavage , positive control drug group give Hugan the tablets (22.75mg/kg weight ) aqueous solution orally , model control group and normal control group were fed the same volume of distilled water . Twice daily for 2 weeks . After the last gavage , the animals in each group were fasted for 12 hours , abdominal aorta blood collection . Detection of drug - induced liver injury in rats liver function and endotoxin levels to explore Lee jaundice granule the liver JiangMei of , and prevention and treatment of liver injury , and clear the role of endotoxin . Conclusion : Lee jaundice granule role better than Hugan Tablets Groups . Said Ming Lee the jaundice Kang particles have the treatment of drug-induced liver injury endotoxemia good .
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