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Objective: In this study, starting from the inflammation theory , through animal experiments to explore the Qi Bufei Can the regulation of TNF-α , ET -1 the MIF level to improve acute lung injury and provide a new therapeutic methods and approaches for the clinical treatment of . Methods: SD rats were randomly divided into five groups : traditional Chinese medicine , Western medicine , Western medicine group , model group , normal group , n = 10 . Gavage : TCM group and the western medicine group in order to the Qi Bufei square ( raw astragalus , angelica , ginseng , aspartame , Schisandra , licorice ) 2 ml / day by gavage three days remaining group was given saline 2ml / day ; tail vein injection : Western medicine group and western medicine group tail vein injection of dexamethasone 1mg/kg three days , I group 0.5ml saline injection . The third day of each group dealt with accordingly 1 hour after tail vein injection the oleic (0.2ml/kg) the establishment of acute lung injury model ( normal group injected with saline ) , modeling an hour later to collect specimens . Observed activity , breathing and general situation in the rat model , to calculate the coefficient of the lung , and to detect serum and lung tissue homogenates , TNF-α, ET-1, MIF level and compare lung histological changes . Results: Compared with the normal group , lung coefficient , TNF - α , ET -1 , MIF level in varying degrees to improve , the difference between the groups was statistically significant ( P <0.05 ) ; the lung coefficient model group , the normal group minimum , the remaining three sets of data between the drug group , the difference was not statistically significant ( P > 0.05 ) . Five serum the lung homogenates TNF -α , ET -1 , MIF water on average in line with the normal distribution and homogeneity of variance , the treated group were lower than the model group ( P <0.05 ) between the three medication groups ET The -1 level sex difference was significant ( P <0.05 ) . Lung histological changes in the medication group significantly reduced alveolar fibrin exudation ; Chinese Medicines in the western medicine group decreased significantly widened alveolar septum histological changes ( P <0.05 ) was better than the western medicine group , western medicine group model group comparison , despite the differences , but not statistically significant ( P > 0.05 ) was not significantly different between the two indicators group . Conclusions : 1 . Tail vein injection of oleic acid -induced acute lung injury model copied successfully , the Qi Bufei side of dexamethasone on both intervention role , there was no obvious synergies . Qi lungs of acute lung injury . Intervention mechanism related to the decrease of TNF-α , ET -1 , MIF levels of the inflammatory process related early to prevent lung injury in rats .
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