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The Mongolian Medicine Weishuan capsule anti-peptic ulcer research

Author: LiLi
Tutor: WangMinWei
School: Shenyang Pharmaceutical University
Course: Pharmacology
Keywords: Of Mongolian Medicine Weishuan capsule Peptic ulcer Bada dry Gastric ulcer Duodenal ulcer Reflux esophagitis Gastric acid Pepsin Gastric mucus PGE2
CLC: R29
Type: Master's thesis
Year: 2005
Downloads: 75
Quote: 0
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Abstract


The treatment of peptic ulcer disease in Mongolian medicine mainly get rid of the Bada dry evil in this article through the preparation of a variety of peptic ulcer animal model investigated WSA Peptic Ulcer. Continuous 3d after oral administration of experimental animals WSA, 2.8,5.5,11.0 g. kg -1 -dose group can significantly reduce water immersion mice induced gastric mucosal injury area; 11.0 g. kg -1 dose group to reduce the points of aspirin and reserpine-induced gastric mucosal injury in mice; 1.9,3.8,7.5 g. kg -1 dose could significantly inhibit the ethanol-induced rat gastric mucosal lesion length and reduce the area of ??the pylorus ligation rats induced gastric mucosal injury; 6.5 g. kg -1 dose group to reduce the area of ??the guinea pig gastric mucosal injury induced by histamine phosphate. For 10 d give rats the WSA, 3.8,7.5 g. kg -1 dose group significantly reduced acetate impregnated rat gastric volume, increase the rate of ulcer healing. For 3 d experimental animals were given WSA, 11.0 g. kg -1 dose group can reduce the histamine-induced mouse duodenal mucosal damage index; 7.5 g. kg -1 dose group can reduce the cysteamine-induced the rat duodenal ulcer index; 7.5 g. kg -1 dose group reduce reflux esophagitis rat model of esophageal mucosal injury area. 7.5g. kg -1 dose group to reduce gastric free acidity, total acidity. 3.75,7.5 g. kg -1 dose group reduced pepsin activity. Compared with control group 1.9,3.8,7.5 g. The kg -1 dose group of indomethacin-induced rat gastric parietal gastric juice mucus Determination no significant difference 2.8,5.5,11.0 g. kg -1 the mouse gastric wall of PGE dose group of aspirin-induced 2 showed no significant difference. 5.5,11.0 g. the carbon ink advancing speed kg -1 dose group of mice gastric emptying and small intestine of mice; 11.0 g. kg -1 dose group reduce mouse acetic acid writhing, 22.0 g. kg -1 dose group to extend the hot plate mouse pain threshold. The maximum in the acute toxicity test in mice administered an amount of 49.6 g. kg -1 . WSA has a certain role in the treatment and prevention of peptic ulcers in experimental animals, its mechanism of action may be due to the WSA have protected the gastric mucosa, a kind of neutralize stomach acid, reducing the activity of pepsin, but it also has analgesic effects, thus WSA low toxicity with good development prospects get rid of the Bada dry evil drug.

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