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Background systemic lupus erythematosus (systemic lupus erythematosus, SLE) is a produce a variety of autoantibodies, organ connective tissue disease characterized by the formation of immune complexes and attack multiple system. The rate of renal involvement is highest, approximately 75% of patients in clinical renal involvement, renal biopsy found that kidney damage about 80% to 90%, the autopsy found that the rate of almost 100%. Have a higher rate of cardiac involvement, about 70%. But because most of cardiac involvement in lupus patients (about 50%) were asymptomatic, clinically easily overlooked. As early as 1981, some scholars of SLE heart damage description, have subsequently been proposed to improve the detection rate of heart damage detection means. Followed by a multi-center prospective study pointed out that the high mortality of heart damage caused by SLE, second only to infections and renal failure. Since then, national scholars clinical description and summary of the different aspects of cardiac involvement in SLE. But so far at home and abroad, is still a lack of clinical studies of a large sample of lupus heart damage. Objective To investigate the clinical features of systemic lupus erythematosus (SLE), heart damage and to analyze the correlation of age, sex, disease duration, disease activity and laboratory parameters with SLE heart damage. Methods questionnaire collected in the form of clinical data of patients with Epi Info 6.0 and SPSS15.0 software package for statistical analysis, clinical data retrospective analysis of 795 patients with SLE heart damage. (1) 795 patients, 303 patients (38.1%) with cardiac damage, 15 males and female 288 cases, male to female ratio 1:9.2; mean age 36.7 ± 12.2 years; the average duration of 63.6 ± 47.6 months; average diagnostic delay of 23.5. The ② SLE heart damage; especially prevalent ECG abnormalities, among which the common ECG ST-T ischemic changes, including ST-T abnormalities in 212 cases (70.0%), abnormal Q waves in 6 cases (2.0%) and 54 cases of arrhythmia (17.8%). Morphological abnormalities of the heart, including pericardial effusion in 42 cases (13.9%), myocardial damage in 12 cases (4.0%), pulmonary hypertension in 9 cases (2.8%) and valvular disease 24 (7.9%), of which only 24 patients, clinical symptoms, accounting for heart damage for 7.9% of the patients. ③ SLE heart damage mostly asymptomatic, and gender (t = 0.173, P = 0.579) and duration (Z = 2.226, P = 0.207) has nothing to do with disease activity (x 2 = 6.886, P = 0.023) statistics significance. (4) anti-cardiolipin antibodies and SLE heart damage, there was no significant difference in the incidence (x 2 = 0.243, P = 0.622), but relatively close relationship with heart valve damage (x 2 = 2.721, P = 0.013). Conclusion 1 SLE complicated by heart damage often no obvious clinical symptoms. The 2 SLE heart damage may be nothing to do with gender and course of the disease, but the correlation with disease activity, the higher the SLEDAI score, the greater the likelihood of heart damage. 3 anti-cardiolipin antibodies and SLE heart damage was not statistically significant, positive correlation and valve damage. 4 SLE patients with clinical need conventional echocardiography, ECG, antiphospholipid antibody test and SLEDAI score, help to improve the detection rate of heart attack, to prevent and treat.
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