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Association of G+1688A Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 Gene with Myocardial Infarction in the Chinese Han Population

Author: YangYing
Tutor: ChengLongXian
School: Huazhong University of Science and Technology
Course: Internal Medicine
Keywords: platelet endothelial adhesion molecule-1 single nucleotide polymorphism myocardial infarction polymerase chain reaction-restriction fragment-length polymorphism
CLC: R542.22
Type: Master's thesis
Year: 2007
Downloads: 28
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Abstract


Objective PECAM-1 is a member of the immunoglobulin gene superfamily which is expressed on the surface of platelets and leukocytes and at intercellular junctions of endothelial cells. PECAM-1 has led to a reconsideration of its role in cell signaling and plays an important role in the adhesion of leukocytes by modulating the affinity of integrins and in their transendothelial migration. PECAM-1 is also involved in transmitting signals into the cell following its engagement, leading to negative regulation of platelet-collagen interactions. Moreover, a significant role of PECAM-1 is in the transition of intracoronary atheromatous plaques from the stable to the unstable state. The objective of our study is to investigate the association of G+1688A (Ser563Asn) polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene with myocardial infarction (MI).Methods In this study, the G+1688A polymorphism in PECAM-1 gene was detected by PCR-RFLP method (polymerase chain reaction-restriction fragment -length polymorphism) among 802 subjects, including 218 patients with MI and 584 controls. Univariate analysis was first done to compare the distribution of age and sex, then frequencies of alleles and genotypes. Allele frequencies were estimated by the gene-counting method. The differences in the distribution between cases and controls were tested using theχ2, Fisher exact, and Mann-Whitney U tests, where appropriate. Multivariate logistic regression analysis with adjustment for blood pressure level, fasting blood glucose, serum total cholesterol, serum total triglyceride was done to calculate adjusted ORs and 95% confidence intervals (CI).Results There was significant difference in AA frequencies of genotype G+1688A polymorphism between case and control groups respectively (39%vs25%, p<0.001). After adjustment of blood pressure level, fasting blood glucose, serum total cholesterol, serum total triglyceride, Those subjects with the AA genotype presented a significantly higher risk of MI (OR, 2.22; 95%CI, 1.46-3.37). Among the subjects of high serum total cholesterol level or high systolic blood pressure level, the variant AA genotype was associated with high risk of MI (adjust OR, 2.43; 95%CI, 1.08-5.41 and adjust OR, 2.75; 95%CI, 1.64-4.63).Conclusions The single nucleotide polymorphism (SNP) at position +1688 in the exon 8 of PECAM-1 gene is associated with MI and the allele A may be a risk factor for MI in the Chinese Han population.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Myocardial diseases > Myocardial infarction
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