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Speed ??Gan Ning the capsule quality standards improve , and some of its component purification technology research

Author: WangHaiNing
Tutor: FanFeiYue；XieYinZhi；XuWenQing
School: Peking Union Medical College , China
Course: Radiation Medicine
Keywords: Su Ganning Capsule Quanlity Criteria Macroporous adsorption resin Clarify agents separation and purification
CLC: TQ461
Type: Master's thesis
Year: 2008
Downloads: 65
Quote: 0
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Abstract


Su Ganning Capsule is composed by Radix Bupleuri, Dryopteris crassirhizoma Nakai, flos lonicerae, folium isatidis and other traditional Chinese medicine, acetaminophen and chlorpheniramine maleate, both of which belong to Western medicine. Su Ganning Capsule is a prescription combined by the traditional Chinese medicine and Western medicine, which is very effective in heat-clearing, detoxicating and flu-resisting. This experiment erected its quality criteria and made some research in the depuration technology of Dryopteris crassirhizoma Nakai and folium isatidis, in order to prepare for its second development and improvement of its abstaction and depuration technology.The main research work includes:1. The improvement of the quality criteria of Su Ganning Capsule.Besides the identification of chlorpheniramine maleate and Calculus Bovis which is contained in its original quality criteria, the new quality criteria added the identification of flos lonicera, and revised the identification method of chlorpheniramine maleate, as well as the determination of the content of acetaminophen by HPLC, which is well in specificity and reproducibility.2. Separation technology of Dryopteris crassirhizoma Nakai by macroporous adsorption resinsThe technology for adsorbing and separating Dryocrassine from Dryopteris crassirhizoma Nakai with macroporous adsorption resins was set up. The content of dryoerassine was determined by HPLC; the kinds of resin were selected through the determination of adsorption ratio and elution ratio of Dryocrassine in Dryopteris crassirhizoma Nakai in resin; the static adsorption and separation were used in investigating the macroporous adsorption resin; the dynamic adsorption and separation were used in studying the condition of adsorption and separation. Results The results showed that the DM130 macroporous adsorption resin was more suitable in the following technological condition: the sample concentration of tannin in Basket fern rhizome was 0.683 mg / mL; the maximum adsorbing capacity at 6.147 mg / ml; 5BV water and 30% ethanol were used to wash out impurity; the eluting reagent was 50% ethanol(five times as the volume of the resin).The technology for adsorbing and separating tannin from Dryopteris crassirhizoma Nakai with macroporous adsorption resin was set up. The kinds of resin were selected through the determination of adsorption ratio and elution ratio of tannin in Dryopteris crassirhizoma Nakai in resin. The UV spectrophotometric method was used in the determination of tannin content; The static adsorption and separation were used in investigation of macroporous adsorption resin; the dynamic adsorption and separation were used in studying the condition of adsorption and separation. The results showed that the D4020 macroporous adsorption resin was the best for adsorbing and separating tannin from Dryopteris crassirhizoma Nakai in the following technological condition: the sample concentration of tannin in Dryopteris crassirhizoma Nakai was 6.27 mg / mL; the maximum adsorbing capacity was 25.08 mg / mL; PH was 9-10; the eluting reagent was 50% ethanol (four times as the volume of the resin), PH is 5-6.3. Studies on Clarify Agents Used on extract of folium isatidisThe optimum process of Chitosan and ZTC1+1-II natural clarify agents used on extract of folium isatidis was studied. Using the remaining rates of polysaccharide, indirubin and the defecation level as the raw material, the optimum process of removing impurity were investigated with single-factor test. The optimum process conditions were: Chitosan: merging the extract solution, condense to 1:10 (hurb: the hurb solution), in the liquid, the concentration of Chitosan clarify agents was 8%, the temperature was 50℃; ZTC1+1-II: merging the extract solution, condense to 1: 10 (hurb: the hurb solution), in the liquid, the concentration of Chitosan clarify agents was 5%, the adding sequence of ZTC 1+1-II natural clarify agents was clarifier B before clarifier A, the temperature was 70℃.

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