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The Diversity of Tight Junction in the Iris Blood Vessels during Penetrating Keratoplasty

Author: ZhuangXianLi
Tutor: ShiWeiYun
School: Qingdao University
Course: Ophthalmology
Keywords: Immune rejection Penetrating Keratoplasty Iris Tight junctions
CLC: R779.65
Type: Master's thesis
Year: 2008
Downloads: 12
Quote: 0
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Abstract


Objective To study the iris vascular changes in tight junctions with corneal allograft rejection reaction between the relationship further reveal corneal allograft rejection mechanism . Donor C57BL / 6 mice , BALB / c mice as recipients , making penetrating corneal transplantation model 40 . 20 anterior chamber implantation of cyclosporine A drug delivery system ( CSA - DDS) , Group B , I - Group A The Shop applications iris , chip technology , immunohistochemistry and molecular biology examination, the iris vascular CD31 detects different times , tight junction protein Z0- 1 of occludin and matrix metalloproteinase 9 (MMP-9) changes . Results iris stretched immunofluorescence : A group after seven days visible increase in CD31 -positive vascular density , lumen enlargement ; B group after 18 days , the the the iris vascular lumen thicker ; exclusion iris vascular lumen of the two groups rough than normal stiffness out of shape . Eye frozen sections are shown after 7 days : A group , B group after 18 days in mice iris tight junction protein Z0-1 expression was no significant change in the expression of MMP -9 significantly increased ; Z0-1 expression than normal to reduce rejection MMP-9 expression was significantly increased . RT-PCR analysis : A postoperative 3,7,12,18 days MMP-9 expression were higher than normal ; B group 3 day expression increased significantly after a sharp decline , but again higher than the normal 18 days . Group A after three days occludin expression had increased , then decreased gradually and reached the lowest to 18 days , group B showed a slow downward trend . Group A after 3 days , Z0-1 expression was significantly increased in the 12 days , 7 days, 18 days than normal expression decreased . Group B was significantly higher than normal , then decreased gradually , expression and normal 18 days no significant difference . Conclusion corneal allograft rejection reaction occurs the iris angioedema andcoarsen iris angioedema , lumen thicker, tight junction protein Z0- 1 reduced the expression of occluding anterior chamber implantation the CSA can delay this process , the mechanism may be through the inhibition of MMP- 9 expression to achieve.

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CLC: > Medicine, health > Ophthalmology > Eye surgery and surgery > Corneal transplant
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