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Recipe blunt with cinnamon Pharmaceutical Research Pieces

Author: ZhuLan
Tutor: SongYing
School: Chengdu University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: Pieces blunt with cinnamon recipe Preparation Quality standards Stability Acute toxicity
CLC: R286
Type: Master's thesis
Year: 2007
Downloads: 83
Quote: 0
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Abstract


Pieces blunt with cinnamon recipe is a recipe for punch clinically taking cinnamon powder Pieces. In this study, under the guidance of the basic theory of traditional Chinese medicine , Chinese medicine powder and herbal formulas reference particle research model, cinnamon blunt Herbal formulations were systematically studied . Pieces from the recipe with cinnamon cinnamon blunt single herb processing, based on clinical need medication , combined with volatile oil of cinnamon easily escaping this nature , to work out the preparation process routes to particle size and reconstitution of these two indicators , screening out Pieces of the recipe with cinnamon blunt final preparation routes: cinnamon sifted through a 24 mesh sieve , 50 ~ 60 ℃ bake under water to 5 % to 7% was feeding meal , take 4.8Kg placed SYFM-100 vibration mill for pulverization ( medium filling rate of 70%) , pulverized for 30 minutes, adding Tween -80 192g, sucrose 576 g, sodium carboxymethyl starch, 384g, continue pulverized product was collected after 10 minutes . Quality standards , with emphasis on the particle diameter measurement products were studied to establish the use of laser particle size of the product detector test method batches of samples were determined by the tentatively -based products not less than the average particle diameter 10μm; the the product of cinnamic aldehyde content were studied, determined by HPLC cinnamic aldehyde content and conduct a systematic methodological studies , tentatively based products containing cinnamon per g of cinnamic aldehyde to count , not less than 15mg; and dissolvability check the introduction of standards , a comprehensive control recipe with cinnamon blunt Pieces quality . In accordance with the quality standards ( Draft ) and related technical requirements for the stability study , three batches of samples using aluminum composite film bag -packing , after three months at room temperature to stay kind of study, three batches of samples the results of the indicators are in line with requirements. Acute toxicity studies showed that cinnamon powder and recipes with cinnamon blunt Pieces safe dose ranges are larger. These experiments show that: preparation reasonably practicable , controllable quality standards , product safe and effective.

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