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The Studies on Processibility of Polyetherurethanes (PUs) for intravascular Catheters and Surface Modification on the PUs with Cross-linked Coating

Author: WangDeYong
Tutor: ZhongYinPing
School: Sichuan University
Course: Biomedical Engineering
Keywords: Polyurethane Interventional catheter Extrusion processing Surface Modification Lubricity Platelet adhesion
CLC: R318.08
Type: Master's thesis
Year: 2001
Downloads: 272
Quote: 3
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Abstract


Endovascular treatment technology successfully used in clinical greatly reduce the patient's pain and convenience of the doctor's surgical procedure. Endovascular therapy as the primary instrument, endovascular catheters excellent operability and safety for successful intervention is very important. Interventional catheter materials, manufacture, process and so on interventional catheter has great influence on the performance. In this thesis, Department of Polymer Materials, Sichuan University developed interventional treatment with polyurethane (PUs) extrusion processing properties were studied. By thermal gravimetric analysis (TG), differential scanning calorimetry (DSC), Haake torque rheometer, melt flow rate (MFR) and other methods of the extrusion process and is closely related to the decomposition temperature of PUs T_d, m.p. T_m, PUs relative rheological properties, melt flowability. Research shows that between polyurethane T_m and T_d extrusion processing with a wide temperature range, T_m with polyurethane hard segment content increases with; PUs were lower melt viscosity, and with the increase of hard segment content , the melt viscosity decreases, increased mobility. According to the PUs T_m, T_d and relative processing rheology, and the suitable extrusion processing conditions, each of the single-screw extruder and a twin-screw extruder processing. The results show that the conditions are suitable for extrusion, the extrusion process without significant oxidation, degradation and crosslinking reaction, the product surface and excellent performance. Adding 30% to pass the test (total weight) radiation opaque agent is added after the polyurethane (PUs B) tensile strength, elongation at break of a radiopaque agent on the mechanical properties of materials, and found that the tensile strength and elongation at break rates have improved to some extent. Static platelet adhesion in vitro experiments, the extrusion process and found no radiopacity antiplatelet agents for polyurethanes have a significant impact on adhesion properties. This paper presents a structure of interventional catheter, processing program and its extrusion dies. In this study, cross-linked polyurethane monomer mixture with PEO or PVP solution on the interventional treatment with polyurethane four) 11 University master's degree thesis ester of the coating material surface modification. Through water absorption, scanning electron microscopy, surface contact angle, surface lubricity and in vitro static platelet adhesion test and analysis of experiments to study the structure and properties of the modified surface. The results showed that the surface modified with a hydrophobic nature of the anhydrous state, in an aqueous solution of a hydrophilic; modified significantly increased water absorption, and its surface properties of the hydrogel in water with excellent lubrication properties, with the tourbillon or PVP concentration increases, the lubricity increases; analysis shows that the crosslinked PU mountain in the chains of PEO or PVP effective entanglement of the chains to prevent the tourbillon, PVP off from the surface, the modified surface is durable and lubricating properties scratch-resistant; static platelet adhesion in vitro experiments show that, PU-PEO, PU-PVP modified surfaces have good anti-platelet adhesion, platelet activation on a low level, wherein the surface-modified PU-PEO anti-platelet adhesion and activation of better performance.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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