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A Study on Molecular Mechanism of Cognitive Deficits After Traumatic Brain Injury

Author: DongYuWei
Tutor: XiaXueWei
School: Guilin Medical College,
Course: Surgery
Keywords: Traumatic brain injury Cognitive function Postsynaptic density Actin -related protein Dendritic spines Synaptic plasticity
CLC: R651.15
Type: Master's thesis
Year: 2010
Downloads: 56
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Abstract


Objective To establish a rat model of traumatic brain injury (traumatic brain injury, TBI) , the morphology of dendritic spines in the hippocampus of rats and the number of changes observed after TBI postsynaptic dense material -95 (PSD-95) and the actin -related protein 2/3 (ARP2 / 3) complex changes , explore TBI rats with cognitive impairment in synaptic plasticity relations , analysis of molecular biological mechanisms of cognitive impairment caused by traumatic brain injury , and for clinical diagnosis , treatment the theoretical basis for objective molecular biology . 80 healthy adult male SD rats were randomly divided into a control group (n = 35) and traumatic brain injury group ( n = 45) ; brain injury group applications impact acceleration brain injury , traumatic brain injury model . 10 randomly selected control group and brain injury group, 10 rats , the Morris water maze (Morris Water Maze, MWM) Experimental evaluation of learning and memory function in rats ; Golgi (Golgi) staining method to observe the control group (n = 12 ) and brain injury group ( n = 12 ) before and after the injuries of hippocampal pyramidal cells in the top number of tree branch diameter and number ; method used the organization Western blot (Western Blot, WB) observed in rats postsynaptic density -95 and actin -related protein 2 /3 complex traumatic brain injury (n = 5), 3 Tian ( n = 5 ) , 7 days (n = 5) , one day after the expression . Results Compared with the control group , brain damage in rats 1-7 days after TBI significantly longer to find the platform time ; brain injury in rats hippocampal pyramidal apical dendrites branch number decreased significantly , morphological no significant change ; and brain damage in rats in TBI postsynaptic density - 95 and actin -related protein 2 /3 complex were reduced , and with injury time extension , PSD-95 and ARP2 showed a decreasing trend (P lt ; 0.05). Conclusion 1 . Traumatic brain injury in rats in the MWM experiment early spatial cognitive behavioral disorders ; traumatic brain injury in rats reduced the number of dendritic spines in the hippocampus ; traumatic brain injury in rats synaptic reduction of dense matter ; 4. traumatic brain injury in rats appeared reduced actin - related protein complex ; 5 . traumatic brain injury in rats with cognitive impairment and synaptic plasticity .

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Brain > Traumatic brain injury
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