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The Clinical Meaning of Detecting the Level of Blood Serum TNF-α in Rats with Fish Bile Poisoning

Author: HuZuo
Tutor: HeMinHua
School: Dali University
Course: Internal Medicine
Keywords: Fish bile poisoning TNF-α Pathogenesis AKI
CLC: R595.4
Type: Master's thesis
Year: 2010
Downloads: 10
Quote: 0
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Abstract


Objective: To study serum levels of tumor necrosis factor -α (tumor necrosis factor-α, TNF-α) in different time segment of grass carp bile the Toxic Rats changes with fish bile poisoning acute renal injury (acute kidney injury, AKI ) occurred , and the development of relations . Explore the fish bile poisoning the AKI possible pathogenesis . Method: 1. Literature review , reference mentor early research and preliminary experiments to determine the dose gavage of grass carp bile . (2) Preparation of different time periods grass carp bile poisoning rat model . Using ELISA ( Enzyme- linked immunosorbent assay , ELISA ) method was measured 20 different time periods fish bile poisoning rats and 10 normal control rats, serum levels of TNF -α level , comparing fish bile poisoning serum TNF -α and normal control rats serum levels of TNF -α levels compare fish bile poisoning serum TNF-α levels among the groups fresh rat kidney kidney removed according to the different time periods and Renal Pathology extent of damage analysis of fish bile poisoning relationship. Results: grass carp bile poisoning rat TNF-α levels ( 22.30 ± 5.81 ) pg / mL compared with the normal control group (16.23 ± 0.32) pg / mL was significantly higher significant sex difference was statistically significant ( P <0.01 ) . 24h the fish guts poisoning group and 72h fish bile poisoning serum levels of TNF -α level ( 21.33 ± 0.31 ) pg / mL ( 29.33 ± 1.47 ) pg / mL was significantly higher than the normal control group , there were significant differences sexual significant (P lt; 0.01). 72h the fish guts poisoning group TNF-α levels higher than 24h fish bile poisoning group, serum levels of TNF - α Shuiyu significant difference was statistically significant ( P <0.01 ) . 24h the fish guts poisoning group , 72h the fish guts poisoning group , normal control group, serum TNF-α level card compared to each other , 72h fish bile poisoning group gt ; 24h fish bile poisoning group gt ; normal control group , the difference was significant sexual statistical significance (P <0.01). 2 fish bile poisoning the longer and more severity of renal pathological damage . Talasite 3.TNF-a renal pathology is proportional to the degree of damage . Conclusion : 1 . Fish bile poisoning rats AKI modeling success . Heavier fish bile poisoning the longer cause poisoning , elevated serum TNF-α is more obvious , and more severity of renal pathological damage . 33 . Fish bile poisoning pathogenesis and serum levels of TNF - α is closely related to serum TNF-α in fish bile poisoning group fish bile poisoning the onset of AKI and fish bile poisoning AKI occurrence progress .

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CLC: > Medicine, health > Internal Medicine > Systemic disease > Poisoning and chemical damage > Poisoning
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