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Objective To detect atherosclerosis in patients with acute cerebral infarction serum resistin levels, analysis of resistin and the degree of clinical neurological deficit, infarct volume, and blood sugar, blood lipids, and inflammatory markers high-sensitivity C-reactive protein (hs-CRP) were explore the relationship between resistin and cerebral infarction influencing factors. Method on 68 patients with acute anterior circulation in patients with cerebral infarction and 80 normal controls were caught doing the standard height, body mass, waist circumference, hip circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP) measurements and calculate body mass index ( BMI) and waist-to-hip ratio (WHR). Enzyme-linked immunosorbent assay (ELISA) serum resistin concentration, simultaneous detection of fasting serum insulin (FINS), fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL -C), low-density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP), and to analyze the relationship between the above indicators and resistin. Under the U.S. National Institutes of Health neurological deficit score (NIHSS) genotyping in patients with neurological deficit scores the next morning, according to the ratings results divided into mild, moderate and severe groups; admission 3d brain CT or MRI calculated infarct volume, and so divided into small, medium, junior group, followed by analysis of its relationship with resistin. Calculated the quantitative insulin sensitivity check index (QUICKI). Statistical comparisons OUTCOME MEASURES difference between the CI group and normal control group. Single factor correlation analysis, multivariate Logistic regression analysis and multiple stepwise regression analysis method to analyze the correlation of serum resistin prime and other observation indicators. 1, cerebral infarction and control groups showed no significant difference in gender, age, body mass index (P gt; 0.05). 2, cerebral infarction group FPG, TC, TG, LDL-C, SBP, DBP, FINS, hs-CRP, WHR were higher, and HDL-C, QUICKI lower than the control group, the difference was statistically significant (P lt; O.05). 3, acute cerebral infarction fasting serum resistin levels significantly higher than that in the control group, the difference was statistically significant (P lt; O.01). 4, serum resistance to hormone level and clinical data of single factor correlation analysis show, serum resistance level and the SBP, DBP, BMI, FINS, FPG, LDL-C, of ??hs-CRP was positive related (P lt; 0.05); and HDL -C, QUICKI was negatively correlated (P lt; 0.05); with TC, TG, WHR related to sex (P gt; 0.05). 5, resistin as the dependent variable, cerebral infarction cerebral infarction group influencing factors as independent variables stepwise multiple regression analysis showed that the resistance the prime and BMI, SBP, hs-CRP was positively correlated (P lt; O.05), with HDL, SEX, QUICKI was negatively correlated (P lt; O.05). 6, multivariate unconditional logistic regression analysis showed that the cerebral infarction and Age, Resistin, SDP, TG was positively correlated (P lt; O.05); HDL-C, QUICKI was negatively correlated (P lt; O.05). Conclusion: 1, resistin hyperlipidemia important factors of cerebral infarction. 2 resistin levels in the serum of patients with acute cerebral infarction, infarct volume, severity. 3, serum resistin levels there are gender differences in men than in women.
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