Dissertation > Excellent graduate degree dissertation topics show

Expression and Significance of VEGFR-2 and PDGFR-α in Pheochromocytomas/Paragangliomas

Author: HuangHouFeng
Tutor: LiHanZhong
School: Beijing Union Medical College
Course: Department of Urology
Keywords: pheochromocytoma paraganglioma vascular endothelial growth factor receptor 2(VEGFR-2) platelet derived growth factorα(PDGFR-α) target therapy
CLC: R736.6
Type: Master's thesis
Year: 2010
Downloads: 19
Quote: 0
Read: Download Dissertation

Abstract


[Objective]To study the expression of vascular endothelial growth factor receptor 2 (VEGFR-2) and platelet derived growth factorα(PDGFR-α) in benign pheochromocytomas, malignant pheochromocytomas and normal adrenomedullary tissue. To discuss the value in distinction between benign and malignant pheochromocytomas and the significance in the target therapy for malignant pheochromocytomas.[Methods]The expression of VEGFR-2 and PDGFR-αwas assessed in the 16 benign pheochromocytomas (group A),18 malignant pheochromocytomas (group B) and 6 normal adrenomedullary tissue (group C) by immunohistochemistry. The numbers of positive cells and degrees of expression of VEGFR-2 and PDGFR-a were observed and scored under high power lens for each group. Differentiation was analyzed by the Chi-Square test. Expression of VEGFR-2 and PDGFR-αwas compared between pheochromocytomas and paragangliomas, functional tumors and disfuctional tumors, major tumors and minor tumors, single tumors and multiple tumors, malignant primary tumors and metastatic lesions respectively.P value less than 0.05 was regarded as statistical significance. Data were analyzed by SPSS software.[Results]1、Expression of VEGFR-2 was observed in all pheochromocytomas/ paragangliomas. Most of benign tumors showed positive or mildly positive expression, and most of malignant tissue showed positive or strongly positive expression, and normal adrenomedullary tissue showed mildly positive or negative expression. There was significant difference between each group(P<0.05). Expression of VEGFR-2 in pheochromocytomas was stronger than that in paragangliomas, and there was significant difference between each other (P<0.05). There was no significant difference between functional tumors and disfuctional tumors, major tumors and minor tumors, single tumors and multiple tumors, malignant primary tumors and metastatic lesions respectively (P>0.05)2、Most of benign and malignant pheochromocytomas/paragangliomas and normal adrenomedullary tissue showed mildly positive or negative PDGFR-αexpression. There was no significant difference between each group (P>0.05). There was no significant difference between different sites of tumors, functional tumors and disfuctional tumors, major tumors and minor tumors, single tumors and multiple tumors, malignant primary tumors and metastatic lesions respectively (P>0.05)[Conclusion]1、The expression level of VEGFR-2 might be used as one marker to differentiate benign and malignant pheochromocytomas/paragangliomas. Up-regulation of VEGFR-2 might play an important role in the growth and development of malignant pheochromocytomas/paragangliomas. Thus, VEGFR-2 might be one of targets to treat malignant pheochromocytomas/ paragangliomas.2、PDGFR-αcan not be used as a marker to differentiate benign and malignant pheochromocytomas/paragangliomas. PDGFR-αmay not play an important role in the growth and development of pheochromocytomas/ paragangliomas. PDGFR-αmay not be one of targets to treat malignant pheochromocytomas/ paragangli omas.

Related Dissertations

  1. Analysis of SDHB、SDHC and SDHD Gene Mutations in Head-and-neck Paragangliomas,R739.91
  2. Laparoscopic treatment of adrenal pheochromocytoma and compare the efficacy of open surgery,R736.6
  3. Expression and Significance of IGF-Ⅱ and bFGF in Adrenal Disease,R736.6
  4. IGF-1 Protects Dopaminergic Neurons from L-DOPA-induced Toxicity Via the JAK/STAT Pathway,R742.5
  5. Construction、Verification and Selection of Human Nature High-capacity Gastric Cancer Ribosome Display Single-chain Fv Library,R735.2
  6. A Comparative Study of Laparoscopic and Open Adrenalectomy,R699
  7. NF-κB and iNOS in the adrenal tissue disease characteristics and significance,R586
  8. Systematic Review of Recommendations and Evidences in Guidelines for the Diagnosis of Pheochromocytoma,R736.6
  9. The Analysis of Adrenal Pheochromocytoma Clinical Effects with Laparoscopic Treatment,R736.6
  10. The Cytoprotective Role of Sodium Nitrite Preconditioning Against the Peroxide-Induced Damage in PC12 Cells,R965
  11. Related Analysis of Various Factors of Adrenal and Extra-adrenal Pheochromocytoma in Hospital and Follows-up,R736.6
  12. Multi- Target for the Treatment of Lupus Nephritis Efficacy and Safety Analysis,R593.242
  13. Pilot Study on the Antioxidation Activity in Vitro and Mechanism of Feruloylated Oligosaccharides Extracted from Maize,R285
  14. Effects of Exogenous Hydrogen Sulfide on Amyloid Precursor Protein/Beta-Amyloid Processing and the Expression of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 in Pheochromocytoma Cells,R749.16
  15. Clinical Analysis of 215 Cases with Adrenal Pheochromocytoma,R736.6
  16. Epidermal Growth Factor Receptor Gene Mutation and the Molecular Target Therapy of Late Period Non-small-cell Lung Cancer,R734.2
  17. The Analysis of Factors Associate with Intraoperative Blood Pressure Fluctuation in 15 Cases with Extra-adrenal Pheochromocytoma,R736.6
  18. Retroperitoneal Laparoscopic Adrenalectomy for Pheochromacytoma Compared with Open Surgery,R736.6
  19. Clinical Analysis of 41 Patients of Pheochromocytoma,R736
  20. Study on the Gene Related to Pheochromocytoma and the Effects of Inflammatory Stress on LDL Receptor Expression in Liver,R736.6

CLC: > Medicine, health > Oncology > Internal endocrine tumors > Adrenal tumors
© 2012 www.DissertationTopic.Net  Mobile