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Factors Influencing Injectate Spread After Alcohol Block of Rabbits’ Tibial Nerves

Author: ZhuJie
Tutor: LiJianAn
School: Nanjing Medical University
Course: Sports Medicine
Keywords: Nerve dissolution technique Tibial nerve Ethanol Proliferation
CLC: R744.8
Type: Master's thesis
Year: 2009
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Abstract


Objective: To investigate the bolus speed , ethanol concentration and capacity in the organization of the ethanol diffusion characteristics provide the basis for dissolving the clinical applications of neural technology . Methods : 27 New Zealand white rabbits , 54 tibial nerve stem , divided into three groups . Electrical nerve stimulation apparatus guided accurately locate the tibial nerve stem labeled with a non-ionic iodinated contrast agents , injection of ethanol . Group I ( bolus speed group ) tibial nerve 18 , is divided into three sub - groups ( Ia , Ib , Ic ) , respectively, to accept in order to the bolus speed ( 0.004 ml / s ; 0.01 ml / s ; 0.1 ml / s ) injection 0.3mL anhydrous ethanol. Group II ( concentration group ) tibial nerve stem 12 , is divided into two subgroups ( IIa , IIb ) were treated with bolus 0.01ml / s speed injection 0.3mL of 50% ethanol and anhydrous ethanol . The 24 Group III tibial nerve , divided into four subgroups (III a , Ⅲ b , c III Illd ) , were treated with the injection of ethanol and 0.1 ml of 0.01ml / s injection speed , 0.3ml, 0.5ml, 1.0ml . 10min after injection line 16-slice spiral CT scan calculate the volume of ethanol diffusion , and three-dimensional reconstruction of the image line ethanol diffusion was observed . Results : Ic subgroup ethanol diffusion volume was significantly higher than that in Ia, Ib subgroup (P lt; 0.05). Concentration of ethanol has no effect on ethanol diffusion volume ( P gt; 0.05 ) . The capacity group among subgroups comparative found among subgroups of ethanol the diffusion volume were significant differences ( P lt; 0.05 ) . Proliferation was vertical proliferation capacity of each sub- group diffusion lengthwise were 2.1 ± 0.2cm , 3.6 ± 0.3cm and 4.4 ± 0.3cm and 6.2 ± 0.3cm , 1ml ethanol proliferation of rabbit femoral shaft full length 1 / 2 lengthwise . Conclusion: The ethanol diffusion morphology of longitudinal the bolus speed and capacity significantly affect ethanol diffusion volume , but the ethanol concentration has no effect on the proliferation of volume . Select the minimum capacity to achieve a therapeutic effect of clinical ethanol nerve block or reduce the speed of the bolus to avoid excessive proliferation of the ethanol to increase in the target selective nerve block in order to avoid non-target nerve damage , muscle atrophy and other adverse reactions .

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Spinal cord disease > Motor Neurone Disease
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