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Objective: To evaluate different doses of ondansetron to prevent laparoscopic cholecystectomy efficacy of postoperative nausea and vomiting . Methods: female patients undergoing elective laparoscopic cholecystectomy in 140 cases , aged 30-60 years old, according to the dose of ondansetron (0mg, 0.5mg, 1.0mg, 2.0mg, 4.0mg, 8.0mg and 16.0 mg ) were randomly divided into 7 groups of 20 cases. Propofol , fentanyl and atracurium amine anesthesia induced by endotracheal intubation , mechanical ventilation, sevoflurane , fentanyl and Atracurium maintain anesthesia , adjust the concentration of sevoflurane to maintain mean arterial pressure ( MAP ) , heart rate ( HR ) , the end of the procedure given in accordance with the packet -dose intravenous ondansetron . Incidence ; records within 24 hours of the postoperative nausea and vomiting in patients with severe nausea and vomiting requiring treatment time ; postoperative pain severity and patient satisfaction . : 8 mg group postoperative nausea and vomiting was lower than other groups , and significantly lower than the control group ( 0 mg group ) ( x2 = 7.88 , P = 0.005 ) ; anesthesia satisfaction score of the control group ( 0 mg group) was significantly lower than 8 mg group ( F = 1.54 , P = 0.04 ) ; patients with severe nausea and vomiting of time and frequency with Kaplan-Meier curves 8mg group was better than the other groups , and significantly higher than the control group ( 0 mg group ) ( x2 = 7.93 , P = 0.004 ) . 24h after pain score difference was not statistically significant ( F = 0.26 , P = 0.90 ) . Conclusion: Ondansetron 8mg group of laparoscopic resection postoperative nausea and vomiting preventive effect is optimal .
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