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Research the On-site Method of in Vitro Assay about the Sensitivity of Plasmondium Falciparum to New Compound Antimalarial Dihydroartemisinin/Piperaquine

Author: WangHengYe
Tutor: YangHengLin
School: Dali University
Course: Pathogen Biology
Keywords: Plasmodium falciparum Compound antimalarial Sensitivity In vitro micro- test method
CLC: R531.3
Type: Master's thesis
Year: 2010
Downloads: 38
Quote: 0
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Abstract


Objective 1.1 explore Plasmodium falciparum in vitro on the current development of artemisinin-based combination antimalarial site determination method ; provide medicinal stable , reproducible , valid for at least three months of dihydrotestosterone green lotus prime / piperaquine determination board. 1.2 falciparum malaria endemic areas in Yunnan to carry out the monitoring . Plasmodium falciparum sensitivity monitoring of artemisinin-based combination antimalarial ( dihydrotestosterone Green artemisinin / piperaquine ) to provide technical support . 1.3 understand the dihydroartemisinin / piperaquine compatibility has (or no ) synergies trace assay methods currently used by the WHO standardized in vitro drug susceptibility testing method . The method is developed from 1978 on the basis of in Trager and Jensen vitro culture , the Rieckmann further establish the in vitro determination of antimalarial trace sensitivity technology . It is depending on the growth and development of different drug concentrations on the malaria parasite , completely inhibited by concentrations of certain drugs can be completely inhibited the growth and development of the principle of Plasmodium falciparum , through the optical microscope to evaluate the the antimalarial formation schizont body inhibition. Results of single - drug board determination of the success rate of 76.92% in 2008 , respectively , 75% and 72.41% in 2009 , 75.86 percent success rate of 76.92% ( 2008 ) and 75.86% ( 2009 ; Compound cytotoxic plates determination years), the difference was not significant ; unilateral and complex wells Plasmodium inhibition rates to rise in an orderly manner with the increase of the concentration of the drug ; the two drugs Plasmodium inhibition rate was significantly higher than the unilateral , two drugs 50 % inhibitory concentration (IC50 ) significantly lower than the unilateral , two drugs significantly reduced the amount of drugs . 4 Conclusions 4.1 the homemade Dihydroartemisinin / piperazine potency of quinoline determination board is stable, sensitive , reproducible, and easy to promote the use of field ; 4.2 two drugs associated with significantly reduced the amount of drugs , there are obvious synergies , combination therapy is imperative.

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CLC: > Medicine, health > Internal Medicine > Parasitic diseases > Protozoal > Malaria
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