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Objective: To investigate the to Kundan Granules on diet-induced metabolic syndrome rat model of liver tissue morphology affect its role in the mechanism , to provide experimental evidence for the clinical application of Kundan granules . Methods : 95 male Wistar rats were randomized divided into blank control group 10 and model 85 , the blank control group was given distilled water , the model gavage high fat, sugar , salt emulsion , freedom of the two groups of rats food and water . Six weeks after modeling , modeling successful rats were randomly divided into 7 groups : model group , of Kundan large dose group , Kundan middle dose group , of Kundan small dose group , rosiglitazone group , lovastatin statin group , captopril group , drug intervention for six weeks during the treatment continues gavage high fat, sugar salt emulsion . After the test, the production of liver tissue biopsy , observed morphological changes detected weight , fasting blood glucose , serum insulin , calculated insulin sensitivity index , blood lipids , TNF -α , FFA, leptin . Results: ( 1) Kundan , in dose can significantly improve liver sinusoids and central venous stasis , reduce the portal area and inflammatory cell infiltration , protect liver cells ; ( 2 ) Kundan high-dose group can improve metabolic syndrome in rats the general condition of significantly lower body weight , fasting blood glucose , serum insulin , TG , systolic blood pressure , TNF -α , increased HDL-C, insulin sensitivity index ; (3) the Kundan large , middle dose group can significantly reduce TC LDL-C, FFA, leptin . Conclusion : Kundan granules significantly reduce the role of the liver tissue injury in liver cells , in order to lose weight , hypoglycemic , lipid-lowering , blood pressure, improve insulin resistance ; which may be related Qi and blood , dampness Huazhuo , , reduce TNF -α, FFA, leptin levels .
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