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Study on Deleterious Substances in Coptis, Angelica and Mechanism of Alkaloids in Coptis to Cure Ⅱ Diabetes

Author: LiTieGang
Tutor: LuoWeiZao
School: Chengdu University of Traditional Chinese Medicine
Course: Medicinal Chemistry
Keywords: Angelica Coptis Soil Organochlorine pesticides Organophosphate pesticides Heavy metal Diabetes Alkaloid
CLC: R284
Type: Master's thesis
Year: 2010
Downloads: 80
Quote: 0
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Abstract


Harmful substances in Chinese medicine pesticide residues, heavy metals, aflatoxin toxins, microbial limit exceeded, serious impact on Chinese medicine quality and drug safety, more and more attention of governments and the public, has become one of the main obstacles to restricting the development of traditional Chinese medicine. The Sichuan the important common varieties of Chinese medicine production of Angelica, berberine Department, has a long history of medicinal The current \The papers of different origin, source of Angelica, berberine herbs and their growing environment (soil) organochlorine and organophosphorus pesticide residues research and to develop the maximum residue limits of Radix, select both part The ingredients for heavy metals arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd), copper (Cu) content was measured to provide the basis to standardize herbal medicines all aspects of production, to reduce and eliminate harmful substances in Chinese medicine. Organochlorine pesticide residues in herbs.: Refer Chinese Pharmacopoeia Appendix IXQ using acetone - water extraction system, dichloromethane liquid-liquid distribution, concentrated sulfuric acid sulfonation purification technology in addition to impurities, GC-g-ECD assay herbs organochlorine pesticide residues and formulation of herbs in EMRLs. Organochlorine pesticide residues in soil: Refer to GB / T 14550-2003 standard with acetone - petroleum ether Soxhlet extraction, purification of concentrated sulfuric acid organochlorine pesticide residues in addition to impurities GC-μ-ECD assay soil. Organophosphorus pesticide residues in herbs.: Refer to the \development of MRLs. Organophosphorus pesticide residues Status of soil: Refer to GB / T 14552-93 standard ultrasonic extraction with acetone plus water, and extracted with methylene chloride, condensation removal of impurities by GC-NPD assay of organophosphorus pesticide residues in soil. Determination of heavy metal content: Treatment of samples by microwave digestion atomic absorption spectrophotometry (AAS) and atomic fluorescence spectrometry (AFS) determination of the content of five heavy metals in herbs. Diabetes is a common and multiple diseases, multi-induced insulin resistance and insulin dysfunction. The Coptis treatment diabetic medicinal historic, modern medical research shows that the alkaloids of Coptis in its main material basis for the treatment of diabetes. In this paper, Western blot (Western blotting) to explore the mechanism of Coptis alkaloids anti type II diabetes.

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