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Study of Preventive and Therapeutic Effects of the Extract of Alpinia Officinarum Hance on Vascular Dementia

Author: ChenChunSheng
Tutor: ShenShiGang;ZhaoYanYan
School: Hebei University
Course: Analytical Chemistry
Keywords: The galangal different extract Vascular Dementia Learning and Memory Cerebral vascular permeability
CLC: R285.5
Type: Master's thesis
Year: 2009
Downloads: 47
Quote: 0
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Abstract


This paper made a preliminary study and explore the galangal extract the prevention and treatment of memory impairment in mice mechanism. Chapter 1: Introduction etiology, pathogenesis, and treatment of vascular dementia research advances, and to clarify the research background and significance of the experiment. Chapter II: Galangal extract on scopolamine-induced disorders affect memory in mice were prepared aqueous extract of galangal ethanol extract, methanol extract, ethyl acetate extract and petroleum ether extract; using mice jumping The different extracts Screening galangal water and ethanol extracts initially identified for its effective parts. Step down and Morris water maze visits galangal water and ethanol extracts obtained scopolamine induced memory impairment in mice affect learning and memory abilities; HE staining of paraffin sections to observe the changes in the brain tissue morphology; UV spectrophotometer mice brain tissue acetylcholine transfer enzyme (Choline acetyltrans-ferase, ChAT) and acetyl cholinesterase (True choline esterase, TChE) of vitality; results show that, galangal water and ethanol extract objects scopolamine caused by induced memory acquisition impairment have significant improve the role and galangal water extract improvement, its mechanism of action may be related to the reduce TchE vitality increase ChAT vitality, and enhance central cholinergic nervous system function related. Chapter: Galangal extract sodium nitrite memory induced consolidation of disorders affect the Morris water maze visits galangal water and ethanol extracts of sodium nitrite caused the memory consolidation obstacles ability of learning and memory in mice; paraffin HE staining observed changes in the morphology of the brain tissue; UV spectrophotometer sodium nitrite induced memory consolidation mouse brain tissue superoxide dismutase (Superoxide Dismutase, SOD) activity and malondialdehyde (Maleic Dialdehyde, MDA) content; The results show that, galangal water extract and ethanol extract of sodium nitrite induced memory consolidate obstacles to significant improvement in the role of its mechanism of action may be related to decreased MDA content, SOD activity, enhanced radical scavenging capacity in the brain. . Chapter IV: galangal extract ethanol memory induced reproduction disorders affect mice jumping method visits galangal water and ethanol extracts of oral administration of 40% ethanol induced memory retrieval obstacles to the ability of learning and memory in mice. Chapter V: of galangal extracts of mouse brain vascular permeability bilateral common carotid artery ligation (BCCAO) Preparation mouse model of acute cerebral ischemia, cerebral water content in the wet and dry weight were observed; acute cerebral ischemia model mouse tail vein injection of Evans Blue (Evans blue, EB), UV spectrophotometer - revealing the content of Evans blue cerebrovascular investigated galangal water extract and ethanol extract of acute cerebral ischemia The mice brain vascular permeability changes; Results show that galangal water extract can effectively reduce acute cerebral ischemic brain water content and brain vascular permeability, have a protective effect on the brain blood vessels.

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