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Clinical Efficacy Study of Xian Ling Xiao Yin Capsules on Treatment of Psoriasis Vulgaris

Author: FanRuiFang
Tutor: QiaoHaiLing;LiHongWen
School: Zhengzhou University
Course: Pharmacology
Keywords: The moss Ling xiaoyin capsules Blood heat type psoriasis Deficiency type psoriasis Interleukin -6 (IL-6) C-reactive protein (CRP)
CLC: R275.9
Type: Master's thesis
Year: 2009
Downloads: 31
Quote: 0
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Abstract


Background and Purpose: Psoriasis is a common recurrent erythematous scaly skin disease, commonly known as psoriasis, Chinese medicine called \Various types of psoriasis, psoriasis vulgaris prevalence accounted for 97.98%, there is still no effective therapy. January 2007 to February 2008, we apply the moss Ling Xiaoyin capsules combined with conventional therapy for type psoriasis vulgaris 179 cases, and achieved good effect. Qingrejiedu, Qufeng moistening effect the drug has good efficacy, low recurrence rate, side effects. In this study, 179 cases of moss Ling Xiaoyin capsules in the treatment of psoriasis vulgaris explore the mechanism of moss Ling eliminate silver capsule in the treatment of psoriasis, and provide the basis for the clinical application of moss Ling capsules xiaoyin and. Judge after four weeks of treatment, PASI (psoriasis area and severity index) score; turbidimetric method of C-reactive protein (C-reactive protein CRP); measured by radioimmunoassay of serum interleukin-6 (interleukin-6). Observed the moss Ling Xiaoyin capsule with conventional therapy clinical efficacy for the treatment of psoriasis vulgaris. Methods: The clinical treatment of patients (n = 179) were randomly divided into two groups, the treatment group (92 cases), aged 30.4 years ± 2.6 years, blood heat 58 cases, 34 cases of deficiency type, given conventional treatment plus moss Ling Xiaoyin capsule ; 87 cases of the control group, the age of 32.3 years ± 2.9 years, blood heat 52 cases, 35 cases of deficiency type, given conventional treatment; Differential Treatment of 4 weeks of treatment effects were evaluated by PASI scores biochemical integral. CRP was measured by rate nephelometry; using IL-6 were measured by radioimmunoassay; measurement data using t-test, the use of SPSS11.0 statistical software processing data, the average count data with x ~ 2 (?) ± s test, α <0.05 significant test level, credibility, P <0.01. Results: Histopathological visible hyperkeratosis, parakeratosis, acanthosis, dermal telangiectasia, psoriasis-like pathological changes obvious mononuclear cell infiltration. After treatment, the lesions histopathology significantly improved biochemical integral evaluation also shows significant difference (P <0.05). The results show that the the the the moss Ling xiaoyin capsule plus conventional treatment with simple conventional treatment after treatment, PASI scores of the treatment group (1.80 ± 0.84) was significantly lower than before treatment (2.89 ± 0.91) (P <0.01); Serum interleukin 6 ( The level of IL-6), before and after treatment 215.38 ± 85.23,101.32 ± 57.61, and the control group were 208.78 ± 107.65,135.97 ± 78.26, between the two groups interleukin-6 (IL-6) decreased level of significant difference ( P <0.05), before and after treatment group compared with the significant difference (P <0.01); serum C-reactive protein (CRP) level, treatment group before and after treatment were 9.1 ± 9.3 ± 4.57,3.57 ± 6.75 in the control group before and after 3.36,4.89 ± 7.58. their results show a significant difference (P <0.01) before and after treatment CRP levels between the two groups with significant differences (P <0.05), and compare CRP values ??decreased in the treatment group and the control group before and after treatment group; treatment Group blood heat efficiency (84.5%) and efficiency (91.2%) were higher than that in the control group blood heat (61.5%) and blood deficiency type (68.6%) (P <0.05) deficiency type. After 1 year of follow-up, the recurrence rate of the treatment group, 10.0% lower than the control group, 39.3% (P <0.05). That for serum IL-6, CRP content with PASI scores were positively correlated, thus proving moss Ling Xiaoyin capsule combined with conventional therapy for psoriasis effective than conventional therapy and treatment of unusual silver, for moss Ling xiaoyin capsules crumbs disease mechanisms provide a clinical basis. Conclusion: 1. The moss Ling xiaoyin capsule with the conventional treatment of psoriasis effective than conventional therapy alone Description the moss Ling xiaoyin capsule in the treatment of psoriasis vulgaris efficacy sure. Psoriasis serum IL-6, CRP monitoring results PASI score was positively correlated with its mechanism and interleukin-6 (IL-6), C-reactive protein (CRP) may be relevant. 2. Treatment follow-up year recurrence rate, recurrence rate of the treatment group than the control group, and significantly improve the efficiency of the treatment of psoriasis vulgaris, the curative effect.

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