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Homocysteine Changes and Its Influence Agents in Simple Obese Children

Author: FengXiaoWei
Tutor: WangFangFang
School: Shanxi Medical
Course: Maternal and child health and children's health
Keywords: Obesity Child Lipids Homocysteine
CLC: R723
Type: Master's thesis
Year: 2005
Downloads: 78
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Objective: increased plasma homocysteine ??levels are risk factors of cardiovascular and cerebrovascular disease in children, but relatively little study of children with simple obesity homocysteine ??influencing factors. This article discussed the children with simple obesity plasma homocysteine ??levels change its metabolism-related factors - folic acid, vitamin B 12 , body mass index, lipid metabolism relationship. Provide new ideas for the prevention and treatment of child overweight and obesity. Method: 1, the subjects were divided into 58 cases of simple obesity in children and the control group. Simple obesity children are included in the standard: children with simple obesity group with WHO recommended standard weight for height determination, weight higher than those of the same sex, and 20% of normal children of the same height standard for obesity, 20% 2 9% mildly obese, 30% 4 9% moderate obesity, higher than 50% were morbidly obese, all detected objects except congenital disease, metabolic and endocrine diseases. caused secondary obesity. As a control group of 58 healthy non-obese children. All children from the hospital child health clinics, the Haikou area school health screenings, children's age, gender basic match. 2, the body mass index (BMI) = weight (kg) / height (m 2 ). Collected more than 12 hours of fasting venous blood using HPLC analysis (HPLC) method to detect the concentration of plasma homocysteine ??(Hcy), radioimmunoassay (RI) Determination of plasma folate, vitamin B 12 12 , body mass index, insulin, lipids, and other indicators were calculate the mean, standard deviation, standard error, between the two groups using t test; Shanxi Medical Journal among groups II using analysis of variance; correlation and multiple regression analysis of the variables related trends for the skewed distribution Measurement data logarithmically transformed to achieve approximate normal distribution, and then tested. P lt; 0.05 was considered statistically significant. Data analysis and processing of the with SAS6.12 statistical software package. The results: 1, different gender health or simple obesity children of both sexes plasma homocysteine ??(Hcy) concentrations no significant difference (P gt; 0.05). 2 children with simple obesity body mass index (BMI), homocysteine ??(Hcy), insulin (Insulin, In), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-Ch ) healthy non-obese children compared to significantly higher (P lt; 0.01), high-density lipoprotein cholesterol (HDL-Ch), folic acid (Folic acid, FA), vitamin B12 (VitminB12, VitB12) concentrations were significantly lower (P lt ; 0.01), with the level of blood sugar (Bloodglucose, BS) with no significant difference (P gt; 0.05). Obese children with increasing degree of obesity, blood Hcy, TC, TG, LDL-Ch, In concentration gradually increased, FA, VitB12, HDL-Ch gradually reduce the F-test, the differences were significant sex (P lt; 0.05). Mild obesity in addition to BS, other indicators and the healthy control group differences were significant (P lt; 0.05); moderate obesity and mild obesity, TC, TG, Hcy, LDL-Ch higher HDL-Ch reduce the difference was statistically significant (P lt; 0.05); severely obese and moderately obese comparison of Hcy, TC, TG, LDL-Ch In higher FA, HDL-Ch reduce, the difference was statistically significant (P lt ; 0.05). 4, adjust blood sugar after children plasma homocysteine ??levels with insulin (r = 0.249, P lt; 0.05), body mass index (BMI) (r = 0.606, P lt; 0.01) increases were positively correlated; With folic acid (r = -0.323, P lt; 0.01), vitamin B12 (r = -0.30, P lt; 0.05) increased by the decrease, there is a negative relationship. Multiple regression analysis showed that body mass index, folic acid,

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