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Evaluation of Islet β-Cell Function by Botnia Glucose Clamp in Women with Polycystic Ovary Syndrome

Author: FengJing
Tutor: LiQiFu
School: Chongqing Medical University
Course: Internal Medicine
Keywords: Polycystic ovary syndrome Β-cell function Glucose clamp technique
CLC: R711.75
Type: Master's thesis
Year: 2005
Downloads: 145
Quote: 1
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Abstract


Objective: To understand the β-cell function in patients with polycystic ovary syndrome (PCOS), and to explore the application of glucose disposal index (DI = the ΔI 30 / ΔG 30 × Homa-IS) assess the possibility of β-cell function in patients with PCOS. Methods: 47 patients with PCOS (divided into obese PCOS group, 16 cases; non-obese PCOS group and 20 cases, 31 cases) and age-matched non-obese healthy women (control group) underwent oral glucose tolerance test (OGTT) and Botnia glucose clamp technique, the glucose clamp technique 60min intravenous glucose tolerance test (IVGTT) and 2h high insulin - is sugar clamp technique (referred to as the euglycemic clamp) combined. Insulin sensitivity (IS) assessed using the HOMA model IS index (Homa-IS) and Botnia glucose clamp technique IS Index (Clamp-IS). Clamp-IS with euglycemic clamp the steady-state phase of insulin-mediated glucose metabolic rate and steady-state insulin concentration is expressed as the ratio (M / I, mg · kg -1 · min -1 per μU / ml). Β-cell function (βF) was assessed using the HOMA the model the βF index (Homa-βF) OGTT βF index (ΔI 30 / ΔG 30 ) and IVGTT first phase ( 0 ~ 10min) insulin secretion (Acute insulin response, AIR). There are three calculation methods in AIR, AIR 1 2, 4, 6, 8, and 10min insulin concentrations average appreciation; AIR2 2,4,6,8 and 10min at each time point insulin concentrations average value-added glucose concentration of value-added ratio (ΔI / ΔG); AIR 3 , the area under the curve of 0 to 10min insulin and glucose concentration ratio (INS AUC10 / GLU AUC10 ). DI = the βF index × IS index. Results: BMI and OGTT 2h glucose of obese PCOS group than the control group and the non-obese PCOS group, no significant difference between the two groups after. Clamp-IS differences were statistically significant among the three groups (P lt; 0.0001), non-obese PCOS group and obese PCOS group Clamp-IS, respectively, for the control group, 50 ± 25% and 35 ± 19%. Among the three groups the βF index (Homa-βF of AIR 1 the AIR 2 and AIR of 3 ) the difference was not statistically significant, but PCOS patients has increased significantly especially in the obese. The four non-obese and obese PCOS group glucose disposition index (Clamp-IS × AIR) is lower than in the control group, but between the two groups the difference was not statistically significant. Obtained by OGTT DI (ΔI 30 / ΔG the 30 × Homa-IS) obtained by Botnia glucose clamp technique DI (Clamp-IS × AIR 2 ) was positively correlated (r = 0.54, P lt; 0.0001), the concentration of glucose OGTT at each time point (0, 30, 60 and 120min) was negatively correlated (r = -0.31, -0.39, - 0.41 and -0.52, P the lt; <.05). Conclusion: Whether or not obesity, PCOS patients are likely presence of insulin resistance; PCOS patients sugar stimulus

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CLC: > Medicine, health > Obstetrics and Gynaecology > Gynecology > Other diseases of the female genital > Ovarian disease
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