Dissertation > Excellent graduate degree dissertation topics show

Effect of Dexamethasone on Expressions of NF-κB, MMP-9 and TIMP-1 in Asthmatic Rats

Author: MaXiuQin
Tutor: HuangMao
School: Nanjing Medical University
Course: Department of Respiratory Medicine
Keywords: Asthma Model Rats Matrix metalloproteinase Tissue inhibitor of metalloproteinase factor-1 Nuclear factor -KB Dexamethasone
CLC: R562.25
Type: Master's thesis
Year: 2005
Downloads: 138
Quote: 3
Read: Download Dissertation

Abstract


The purpose of the preparation of the first part of asthmatic rats prepared rat model of asthma . Male SPF Wistar rats 18 were randomly divided into asthma group, dexamethasone group and control group , n = 6 . Asthma group and dexamethasone group in 1,8 days per intraperitoneal injection of antigen suspension 1ml ( containing the chicken ovalbumin 100mg and aluminum hydroxide dry powder 100mg dissolved in saline ) sensitization ; 15 days began to fog of asthmatic inhalation of 1% ovalbumin , 1 day , each time 20 min , for four consecutive weeks . Daily excitation hour ago , dexamethasone group first intraperitoneal injection of dexamethasone 2mg/kg. Control group, normal saline line sensitized and challenged daily , each 20min, continuous inhalation of four weeks . Last atomized 24h, with 20% urethane 2g/kg , intraperitoneal injection of anesthesia , tracheotomy cannula and jugular vein puncture and fixed , then the ventilator spirometer , intermittent injection of saline through the jugular vein and 10 , 20,40,80,160,320 g / kg gradient concentration of acetylcholine ( ACh ) , at intervals of 2min, after the detection basis expiratory airway resistance and medication expiratory airway resistance , expiratory airway resistance ( Re ) changes in response to airway responsiveness . Results three groups on the basis of the Re no difference ( P gt ; 0.05 ) , no significant reaction saline excitation . Excited Ach , each group 10μg/kg 20μg/kg a 40μg/kg Ach amount of Re doubled ( when compared to saline Re, the ratio lt ; 1 times ) ; 80μg/kg Ach amount , the asthma group Re obvious multiplication ( gt ; 2 times ) , control group and the hormone group similar reaction ; Ach 160μg/kg amount of asthma and hormone group Re multiplier ( gt ; 2 times ) , the control group Re classless

Related Dissertations

  1. EDM Electrode Wear Mechanism and Control Research,TG661
  2. Design and Research on Stabilization Loop of Gyro Stabilized Pod Control System,V241.5
  3. Temperature Drift Modeling and Compensation of Fiber-Optic Gyroscopes,V241.5
  4. The Study of Control Algorithm for Automotive Power Window Based on Lin Bus,U463.6
  5. High school politics,the new curriculum reform classroom teaching model to integrate exploration,G633.2
  6. The Maneuvering Target Tracking Research Based on VRPF,TN957.52
  7. Fault Diagnosis Research on Three-Tank System,TP277
  8. Analysis and Control of 6-DOF Electrical Driven Parallel Manipulator,TP242.2
  9. The Study on Risk Evaluation of BOT Projects in China University,G647
  10. Vocational colleges teaching effectiveness evaluation model analysis,G712.4
  11. Shandong Province,university research projects Integrated Management Model,G644
  12. Research on University’s Energy Saving System Facing the Construction of Green University,G647
  13. The Research on Evaluation Method of Highway Ecosystem Healthy,X826
  14. Research on the Regional Difference and Influence Factors of China’s Carbon Emissions,X502
  15. Research of Graduates’ Educational Satisfactory Evaluation in Heilongjing Province Based on LISREL Model,G643
  16. Modelling Phycocyanin and CDOM Concentration from Hyperspectral Reflectance Data in Lake Taihu,X87
  17. A Study on the Predictive Model of Health Assessment in Li River, Guiling, Guangxi,X826
  18. The Research of Land-Use Optimization Approach Based on Non-Point Source Pollution Controlled,X24
  19. Research on the Revenue Distribution of PPP Mode about High-speed Railway Project,F283
  20. In Jiangsu Province a Dominance Evaluation of Cropping Pattern Bassed on the Comparative Advantage Theory,S344
  21. Parasitism Preference and Offspring Performance as Affected by Host Species and Captive Breeding in Meteorus Pulchricornis,S476.3

CLC: > Medicine, health > Internal Medicine > Respiratory system and chest diseases > Trachea and bronchial disease > Bronchial disease > Bronchial asthma
© 2012 www.DissertationTopic.Net  Mobile