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Objective: pregnancy induced hypertension ( PIH ) is a common serious obstetric complications , leading to perinatal morbidity and mortality female child one of the main , its etiology and pathogenesis has not yet been fully elucidated. Recent studies propose leptin, hyperinsulinemia, insulin resistance and the incidence of pregnancy-induced hypertension have a certain relationship , determined by specific peripheral blood insulin levels are correct evaluation of insulin resistance and pancreatic B -cell function key . Through this study, patients with PIH and normal maternal blood leptin (leptin, Lep), insulin (insulin, I), true insulin (ture insulin, Ti), proinsulin (proinsulin, Pi), glucose (glucose, Glu) the determination of normal pregnant women with PIH understand leptin levels , insulin resistance, pancreatic B cell function differences , seeks to clarify the leptin and insulin resistance in the pathogenesis of preeclampsia and the significance of the relationship between , so as to study the pathogenesis and treatment of PIH new ways to provide a theoretical basis . Methods: Enzyme-linked immunosorbent assay 50 cases of PIH ( experimental group ) and 30 normal pregnant women ( control group ) in the peripheral blood leptin, true insulin , proinsulin levels ; application of insulin by radioimmunoassay level ; application glucose was measured fasting glucose levels . Calculation proinsulin / insulin true (proinsulin / true insulin, Pi / Ti) ratio represents islet B cell function ; insulin sensitivity index (insulin sensitivity index, ISI) that fasting insulin and fasting glucose values ??represent the results of the degree of insulin resistance down . Experimental data are expressed as mean ± standard deviation or geometric mean ± standard deviation, skewness
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