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The Action of Etomidate on GABA_A Receptors in the Sacral Dorsal Commissural Neurons

Author: HongZuo
Tutor: LiJiShuo；WangDianShi
School: Fourth Military Medical University
Course: Human Anatomy and Embryology
Keywords: Etomidate Anesthetics Visceral pain Spinal cord Nystatin Whole cell patch clamp Capsaicin Rats
CLC: R965
Type: Master's thesis
Year: 2005
Downloads: 35
Quote: 0
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Abstract


Afferent co- sacral dorsal nucleus (Sacral dorsal commissural nucleus, SDCN) located in the sacral spinal cord central canal of the dorsal gray matter , the major recipient of pelvic organs , pelvic visceral sensory information in this relay, the pelvic visceral nociceptive information transfer important nuclei is an ideal target for the study of pelvic visceral pain signal transmission and regulation . Etomidate ( Etomidate ET ) is a short-acting intravenous anesthetics fast , because of its rapid onset of respiratory , circulatory system of small, non-addictive exact tolerance and analgesic effect , etc. , which have been widely clinical application. That it might play anesthesia spinal cord upper brain neurotransmitter -gated ion channel regulation . However, ET can act SDCN, and thus play a local analgesic effect of pelvic visceral pain is not clear . In order to clarify the role of ET in SDCN study two methods : (1) the use of nystatin perforated whole cell patch clamp recording method of the ET -activated currents in acutely isolated rat SDCN neurons pharmacological school characteristics and its regulatory role the GABA_A receptor ; (2 ) the use of capsaicin ( capsaicin CAP ) injected into the rectum due to visceral pain model , intrathecal intubation given different concentrations of ET sacral local observation of animal behavior alterations to clarify the drug in vivo and its clinical value . The study results are as follows :

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