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Objective: secondary sensitization made ??rat model of asthma , to explore the relationship of airway remodeling MMP-9/TIMP-1 expression and asthma pill intervention role , and in contrast with dexamethasone , trying opened flat asthma pill mechanism to treat asthma . Methods: The rat model of asthma , the use of immunohistochemical techniques combined with computer pathological image analysis system for determination of morphological parameters of the four groups of rat airway and bronchial epithelial cells MMP-9/TIMP-1 expression relative content . The result : the bronchial the Explorer wall thickness and smooth muscle thickness in asthma model group was significantly higher than the control group ( P lt ; 0.01,0.01 ) , dexamethasone group (P lt; 0.05,0.05) , and antiasthmatic pill group (P lt ; 0.05 0.05 ) , the dexamethasone group and asthma pill group compared to both no difference (P gt; 0.05) asthma model group, MMP -9 and of TIMP- 1 expression in airway mucosal epithelium was significantly higher (P lt ; 0.01,0.01 ) , dexamethasone group ( P lt; 0.01, 0.05) and asthma pill group ( P lt; 0.01, 0.05) compared to both no difference in the dexamethasone group and asthma pill group (P gt ; 0.05). Conclusion: MMP - 9 overexpression of MMP-9/TIMP-1 imbalance , play an important role in the pathogenesis of airway remodeling in rats with asthma , and asthma pill and dexamethasone play the same anti-inflammatory effects by down-regulating MMP -9 expression regulation the MMP-9/TIMP-1 balance between intervention airway remodeling in asthma , which play the role in the treatment of asthma .
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