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Objective: type 2 diabetes, there is a significant genetic heterogeneity , and are subject to a variety of environmental factors , insulin resistance (IR) and pancreatic dysfunction is the central link in its incidence . Lipid metabolism is often an early event in the pathological process , is also one of the characteristics of the IR ; compensatory hypertrophy and hyperplasia of islet β-cell metabolic load increases , on the other hand , the hypertrophy of the islet β-cells are easy to apoptosis function easy disorders increased β-cell apoptosis causes insulin secretion decrease in the amount of cells , eventually leading to islet failure . In clinical diabetes , islet cell apoptosis is very significant , and in recent years, studies have shown that β-cell apoptosis in type 2 diabetes early events . For diabetes, in medicine , kidney and blood stasis theory to explain its cause , and that Diabetes is Diabetes disease areas . This study on the basis of traditional Chinese medicine for the treatment of Diabetes Disease \This side has Yin Qi , Gushen the the diabetes, the effect of thinning the blood Tongluo . The purpose of this study is to : 1 through long-term high-fat diet , observe the normal rat glucose-stimulated insulin secretion , islet cell apoptosis and β-cell mass , to explore the significance of lipotoxicity in the pathogenesis of diabetes ; 2 observation of compound Chinese medicine Yuye soup of the CD on the long-term high-fat diet rat islet cell apoptosis , β -cell mass and glucose-stimulated insulin secretion , the protective effect of compound traditional Chinese medicine on the islet lipotoxicity . Methods : 60 healthy 8-week-old male SD rats , weighing 208 ± 20g, provided by the Experimental Animal Center of Hebei Medical University . Were randomly divided into four groups (n = 15): normal diet group (NC, normal control group , fat calorie percentage of 13 % ) , high - fat diet group ( HF , fat accounted calorie percentage of 55% ) , high fat diet plus two
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