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Study on Mechanism about the Treatment of Invigorating Spleen and Promoting Resisting Blood by Regulating Qi Chronic Pancreatitis Fibrosis

Author: WangYanMing
Tutor: LiuHuaSheng
School: Heilongjiang University of Traditional Chinese Medicine
Course: Basic Theory of Traditional Chinese Medicine
Keywords: Fibrosis of Chronic Pancreatitis Spleen-asthenia syndrome The treatment of invigoratmg spleen and promoting blood by regulating qi YI TAI Compounded Medication transforming growth factor-β1 α-smooth muscle actin
CLC: R259
Type: Master's thesis
Year: 2005
Downloads: 82
Quote: 1
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Abstract


Chronic pancreatitis(CP) is a kind of commonly seen digestive disease which typical pathological representation is fibrosis of pancreatic texture.The CP incidence has an increasing tendency in recent years. It has threatened human health because of its bad progonosis as well as difficult to cure.Recent researches has demonstrated the key point to restrain the expression of transforming growth factor-β1 (TGF-β1 ) and α-smooth muscle actin (α-SMA ) protein and activation in the anti-fibrosis treatment process.As for the treatment of CP ,Wesern Medicine Limits in symptom improve ment,while Tradditional Chinese Medicine has priority of poly target 、 poly pathway and less side-effect." Yi TAI Compounded Medication "we used bases on the basic theory of TCM,set up "The treatment of invigoratmg spleen and promoting blood by regulating qi",target defiency in origin and excess in superficiality TCM syndrome nature,and take experiments;our research injecting L-Arg into abdomen to induce Spleeh-asthenis rat model,it is a new model which combine diseases and syndromes;immunohistochemic 、 optical mirror and biochemistry value number index number are used to detect the expression of related constrain factor TGF-β1 mRNA、α-SMA when textnre fabrosis occurs in pancreatic,as nell as significance and relation of hydroxyproline in the process of pancreatic fibrosis,meanwhile observe the disturbace which "Yi TAI Compounded Medication" makes,revel the anti-fibrosis mechanism from organization form and molecular level.The study cosequence are followed. " YI TAI Compounded Medication" can constrain the expression of TGF-β1 and α-SMA, through constraining the activation of pancreatic stellatecell to

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