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Objective: To analyze the mask bi-level positive airway pressure (BiPAP) in the treatment of chronic obstructive pulmonary disease with type II respiratory failure and summarize relevant experience and experience to guide clinical practice . Methods : on the basis of conventional medication , application of noninvasive positive pressure ventilation (BiPAP) treatment of COPD with type II respiratory failure in 40 cases , the observation and treatment of the clinical status of patients before and after , vital signs ( respiratory rate , heart rate , blood pressure ) and blood gas analysis change indicators (PaO2, PaCO2) and ventilator-associated adverse reactions . Results : 40 patients , 32 cases effective by clinical status improved significantly ( improved consciousness , respiratory rate slowed down , dyspnea ) , improved and discharged ; ineffective treatment in eight cases of disease progression (5 deaths , 2 patients were discharged 1 cases to accept endotracheal intubation and invasive ventilation ) , the total efficiency of 80% . The patients ventilation therapy before , after breathing frequency (24 ± 4) beats / min (20 ± 4) beats / min , both have significant difference , P lt ; 0.05; ventilation before treatment , after heart rate ( 110 ± 17) / min (91 ± 22) times / min , there was significant difference , P lt ; 0.05; ( 124 ± 17 ) / ( 75 ± 11 ) mmHg in blood pressure before treatment , after treatment (120 ± 17) / (72 ± 9) mmHg, there was no significant difference , P gt ; 0.05 . Before ventilation in patients after PaCO2 levels , respectively (76 ± 20) mmHg and ( 63 ± 17 ) mm Hg , there are significant differences , P lt ; 0.05; ventilation initial improvement after conventional treatment of hypoxia ( PaO2 gt ; 60mmHg ) 26 patients , the PaO2 ventilation , rear , respectively (81 ± 24) mmHg ( 74 ± 20 ) mm Hg , there was no significant difference , P gt ; 0.05; routine treatment before ventilation still PaO2 lt ; 60mmHg for 14 patients , the PaO2 ventilation before and after were (44 ± 11) mmHg ( 64 ± 19 ) mm Hg , contrast there is a significant difference , P lt ; 0.05 . Observed ventilator-associated adverse reactions : five cases with varying degrees of abdominal distension , seven cases of dry mouth, two cases can not tolerate the mask , two cases of ventilator dependence , all patients had no barotrauma , nosocomial infections or ventilator-associated pneumonia other complications occurred. Conclusion : Noninvasive positive pressure ventilation ( BiPAP ) used in patients with chronic obstructive pulmonary disease (COPD) and type II respiratory
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