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The Preliminary Observation of CD34 Antibody Coated Stents to Prevent In-stent Stenosis of Artery Injured by Balloon

Author: CaoHuaMing
Tutor: SuHai；WangXiaoHua
School: Jiangxi Medical College
Course: Internal Medicine
Keywords: CD34 antibody Stand Narrow Endothelial precursor cells
CLC: R541.4
Type: Master's thesis
Year: 2005
Downloads: 74
Quote: 2
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Abstract


Objective: observed in rabbits CD34 antibody coated stent ability to reduce and prevent the the balloon injury stent stenosis . Method : 1. Bracket Development : Comparative gelatin and low molecular weight dextran two stents package substrate , identified by gelatin as a package substrate stent coated , and then package the CD34 antibody . 2 animal model : the left and right femoral artery of New Zealand white rabbits using balloon injury , immediately after injury to the common stent implantation on the right , the left implant antibody bracket ; 14 days sampling a 45 days sampling 3 . OUTCOME MEASURES : ① angiography : stent narrow Percentage : narrow lumen in% = (stent diameter - the diameter of the narrowest point ) / stent diameter × 100 % . The ② pathological examination of the stented segment artery neointimal : OUTCOME MEASURES stent neointimal hyperplasia percentage . Calculate the the bracket enclosed area ( EEM ) , the arterial lumen area that endothelial cells surrounding area ( Lumen ) , neointimal area ( N ) = EEM - Lumen . Cross section artery percentage of N = ( the EEM - lumen ) / the EEL x 100 % ; the ③ bracket at both ends of the arterial wall. : To observe the indicators for both ends of neointimal hyperplasia . (4) data processing and statistics : All data are mean ± standard deviation , using a paired t-test . Results: 1.14 days , the antibody stent segment artery neointimal hyperplasia was significantly lower than the ordinary bracket side . 2.45 days, compared with the ordinary bracket , antibody-coated stent stenosis percentage was significantly down on the ordinary side of the bracket ( 16.13 ± 3.93 VS 47.03 ± 11.89 , P lt ; 0.05 ) ; 3 . The stent segments artery neointimal : antibody package artery stent segment neointimal percentage than ordinary stent segment arteries was significantly reduced ( 49.64 ± 6.40 vs 66.83 ± 6.00 , P lt ; 0.05 ) 4.45 days , the antibody-coated stent vascular neointimal hyperplasia in the distal end of the distal end than ordinary bracket vascular significantly lighter . However , no significant difference between the proximal end of the artery . Conclusion: gelatin as a substrate package stent is conducive to the CD34 antibody adsorption . 2.CD34 antibody-coated stents can effectively reduce the damaged artery stent stenosis .

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
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