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Background and Purpose opioids are widely used in clinical analgesic . However, opioid easy to produce drug resistance , in order to maintain their efficacy, treatment must be repeated and increasing doses lead to drug dependence. In recent years, exogenous opiate abuse has become an increasingly serious social problems , drug and drug to become one of the hotspots of global concern , but also a major medical research one of the difficulties . Since the 1970s , at home and abroad mechanism of opioid dependence have done a lot of research, and made a series of progress , proposed many theories , such as ultra -sensitive theory, metabolic defects hypothesis, opioid receptor down doctrine , cAMP ( cyclic AMP ) system theory and raised cAMP responsive element binding protein (CREB, cAMP response element binding protein) , said phosphoric acid chemistry , etc., but still did not get the ideal opioid dependence explanation. In recent years, excitatory amino acids and their receptors, receptor systems involved in the molecular mechanisms of opioid dependence increasing attention . Long-term opioid dependence and tolerance process, excitatory amino acid receptors ( NMDA receptors primarily ) a compensatory increase occurred and ultra sensitization, and can promote neuronal plasticity and overall biological behavior change. In addition, the opiate addiction process, a large study found that memory was pathological memory impairment, is pathological enhancement . In the treatment of opioid addiction , the overall impact of behavior is a method of detoxification of drugs and drug efficacy objective and scientific decision index . Acidic peptide (AP, Acidic Peptide) is widely distributed in the central nervous system , regulating the nervous messaging and important information material . An jade will wait first isolated in the international arena , a new acidic peptide (AP), the peptide small molecule peptide , non-antigenic , and applied to drug research . In the study suggested : ① AP inhibit excitatory effects of morphine and within the experimental concentration does not have addiction ; ② AP can effectively treat
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