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Background and purpose of acute cerebral infarction is a brain disease that seriously endanger people's health, it can cause a range of acute clinical symptoms and pathological changes, a large number of experiments have shown that the body parts after the onset of inflammatory factors and changes in hormone levels, involved in brain The infarction of development. Previous studies found that: endothelin -1 (ET-1) in the peripheral blood after acute cerebral infarction was significantly higher impact of regional cerebral blood flow increased local injury, to promote the release of the excitatory amino acid and Ca 2 within flow and promote neuronal cell death; elevated insulin (INS) in the peripheral blood of patients with acute cerebral infarction, which usually means that insulin resistance, high blood glucose (FBG) it is accompanied by serious lactic acidosis caused by ischemic brain tissue, causing brain tissue energy metabolism; acute cerebral infarction, tumor necrosis factor-a (TNF-a) changes to induce the expression of inflammatory cytokines, increased endothelial permeability, causing aggregation of inflammatory cells in the ischemic lesion. However, in recent years, while others reported in the literature TNF-a, high FBG play a protective role in ischemic cerebrovascular disease: studies suggest that plasma levels of tumor necrosis factor-a and acute stroke ischemic tolerance related, may be involved in regulation of signaling pathways; ischemic tolerance with good collateral circulation blood supply penumbra of acute hyperglycemia can increase the supply of metabolic substrates to to protect neurons organizations from structural damage. In the development of acute cerebral infarction occurred ET-1, INS, TNF-a, FBG how changes in what role and purpose of the present study. Whether this experiment with hypertension and / non-diabetic, 78 subjects were divided into pure cerebral infarction group, cerebral infarction and hypertension group, cerebral infarction and hypertensive diabetic group, Determination of peripheral blood in its incidence within 72 hours of ET-1 INS, TNF-a, FBG values ??of cases of neurological function and infarct area was measured, and the statistical analysis: clear acute cerebral infarction after the existence of peripheral blood ET-1, INS, TNF-a, FBG level elevated; ET-1, INS, TNF-a, FBG and nerve function scores, whether the infarct size related; correlation exists between the peripheral blood of ET-1, INS, TNF-a, FBG value; in hypertension diabetes exist, the impact and significance of these changes. Provide the basis for future clinical work to identify the impact of cerebral infarction occurred the development of risk factors and aggressive prevention.
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