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Background and Objective: Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) is a global health problem , morbidity and mortality are on the rise , but its pathogenesis has not been fully elucidated . The main characteristic of COPD is not fully reversible airflow limitation , showed progressive development . Airway inflammation (airway inflammation) and airway remodeling (airway remodeling) airway obstruction in patients with COPD , airflow limitation that is not fully reversible pathological basis , is an important factor for COPD occurrence , development and prognosis , especially airway remodeling patients with COPD is not fully reversible airflow obstruction determinants is an important cause of COPD is not easy to cure . In recent years, the role of cytokines and chemokines in the pathogenesis of COPD more and more attention has been paid . Monocyte chemotactic protein -1 ( monocyte chemoattractant protein -1 , MCP -1 ) is a member of the chemokine family CC subfamily , by monocytes / macrophages , fibroblasts , B cell, epithelial cells , endothelial cells, smooth muscle cells and certain tumor cells secretion, chemotaxis and activation of monocytes / macrophages , lymphocytes, in the aggregation of the sites of inflammation , basophils , mast cells and natural killer cells also role , in addition it can also induce fibroblast expression of collagen and transforming growth factor - β . Transforming growth factor -β1 (transforming growth factor beta-1, TGF-β1) has pro Inlet smooth muscle cell proliferation , migration , proliferation of fibroblasts and myofibroblasts transformed and promote extracellular matrix ( extracelluar matrix , ECM ) synthesis, the inhibition of degradation . Currently, many MCP-1, TGF-β1 induced sputum , bronchial alveolar lavage fluid ( BALF ) , research in the airway epithelium , but not yet the serum of patients with COPD MCP - 1 level of TGF-β1 and both relationship between reported . The study measured 29 COPD patients with acute exacerbation of the stabilization period
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