Dissertation > Excellent graduate degree dissertation topics show

Synthesis of Functional Block Copolymer of Polyphosphoester and Their Functionlization

Author: LiYang
Tutor: WangJun
School: University of Science and Technology of China
Course: Biological materials
Keywords: polyphosphoester block copolymer organic catalyst functional micelle
CLC: O631.3
Type: Master's thesis
Year: 2011
Downloads: 42
Quote: 0
Read: Download Dissertation

Abstract


Polyphosphoesters are a series of biodegradable polyesters with repeating phosphoester units in the backbone. Owing to their good biocompatibility in vitro and in vivo and biodegradability through hydrolysis or enzyme catalytic degradation, polyphosphoester raised a lot of attention recently in biomedical applications as drug and gene carriers.The purposes of this dissertation are develop a new method to syntheses block cpolymer of polyphosphoesters by using organic catalyst instead of metallic catalyst to overcome the potential toxicity problem of metallic catalyst and studied the potential functionlization of polyphosphoester. We used poly(ε-caprolatone) as the macroinitiator and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the organic catalyst for the polymerization of ally functional phosphoester monomer 2-allyl-2-oxo-1,3,2-dioxaphospholane (AEP) in THF solution. We used gel permeation chromatography method to study the reaction kinetic of the polymerization and found that the polymerization fit a linear first-order time-conversion plot, therefore we can easily control the molecule weight, molecule weight distribution, composition and structure of the resulting polymer.By using the polymer we obtained above, we applied the“thiol-ene”click reaction to functionalize the polyphosphoester block. A series of amphiphilic block copolymer with various chemical and physical properties can be easily obtained. Micelles with nano-meter sized and special properties are formed by self-assembly of these polymers which may have potential application as carriers in drug and gene delivery.

Related Dissertations

  1. Research on Design of Teaching Buildings for Arts Departments of Higher Learning Institutions,TU244.3
  2. Research and Development of Wear Resistance for Physically Disabled Men Jackets,TS941.2
  3. Reaserch on the Effect of Fabric Structure on the Performance of Seamless Sports Underwear,TS941.15
  4. The Research on the Comprehensive Modification Technology of Rice Protein Enzymatichydrolysis and Graft Copolymerization,TS201.2
  5. Functional Realization of the Competitive Selection System,D262.3
  6. Funcational Verification of Multifunction Vehicle Bus Controllor,TP273
  7. Macrobenthic Secodary Production at Tianhe Inertial, Wenzhou,Q958.8
  8. Cloning and Functional Analysis of Lytic Enzyme Production Related Gene Ctp in Lysobacter Enzymogenes Strain OH11,TQ925
  9. The Research on the Modification and Functional Properties of Rice Glutelin,TS201.21
  10. Study on Host Selection of Encarsia Sophia between Bemisia Tabaci B-Biotype and Q-Biotype Nymph,S476.3
  11. Proteomic Research of Rice Plasma Membrane Protein under Blast Stress,S511
  12. The Genetic Transformation and Functional Analysis of GmFtsH,S565.1
  13. Molecular Cloning and Differential Expression of Isopentenyl-Diphosphate Delta Isomerase 1 Gene from the Fungus Ganoderma Lucidum,S567.31
  14. A Functional Data Based Approach for Studying the Relation of ECG T-wave and RR Intervals,R444
  15. Development of Functional Automotive Interior Textiles,TS106.6
  16. Development Research on Functional Food Ingredien Industry in China,F426.82
  17. The DNA Cloning and RNA Interference of Some Functional Genes in Laodelphax Striatellus (Fallen),S435.112.3
  18. Cloning and Functional Analysis of Proline-Rich Protein Genes in Common Wheat,S512.1
  19. Study on Quantitative Ecology of Quercus Acutissima Communities in Zhongtiao Mountains, Shanxi,Q948
  20. Studies on the Influence of Thiol-Functional Ionic Liquids on CdSe Quantum Dots,O649
  21. Study on Preparation Isolated Proteins and Active Peptides from Pumpkin Seeds,TS201.21

CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Polymer physics and physical chemistry of polymers > The chemical nature of polymers
© 2012 www.DissertationTopic.Net  Mobile