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Studies on the Properties of Oil-in-water Microemulsions and Solubilization of m-Nisoldipine in Tween80-based Microemulsion System

Author: DongQiuXiang
Tutor: HuangChaoLun
School: Hebei Medical University
Course: Pharmaceutical Analysis
Keywords: Microemulsion Pseudo- ternary phase diagrams Between nisoldipine UV spectrophotometry Solubility
CLC: R94
Type: Master's thesis
Year: 2006
Downloads: 394
Quote: 2
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Abstract


The microemulsion is a clear transparent , low viscosity , isotropic and thermodynamically stable oil-water mixing system , by the surfactant and the cosurfactant to a stabilizing effect . Microemulsions as drug carriers in recent years to receive widespread attention , through a variety of ways such as oral, injectable , transdermal , and ocular administration . Surfactant Tween80 for O / W microemulsion system , basic research , and the effects of O / W microemulsion solubilizing effect between nisoldipine . Objective: To study the microemulsion formation and stability Tween80 system influencing factors ; visits Tween80 as surfactant prepared O / W microemulsion solubilizing effect between nisoldipine . Methods: by drawing Tween80 solution surface tension isothermal curve of co- surface-active agent, the surface tension of the Tween80 solution ; drawn by titration the Tween80 a pseudo- ternary phase diagram of the system examines the type of cosurfactant , an oil phase , surface the active agent and the co-surfactant mass ratio ( Km value) , temperature, and drug Tween80 system microemulsion formed . Centrifugation and stay kind observation visits the the blank microemulsion and between nisoldipine microemulsion , stability ; accordance with the Chinese Pharmacopoeia 2005 edition Appendix Ⅵ F refractive index determination method blank microemulsion and between nisoldipine microemulsion , the refractive index ; in accordance with the Chinese Pharmacopoeia 2005 version of Appendix the Ⅵ G viscosity determination Act Determination the blank microemulsion and between nisoldipine microemulsion , kinematic viscosity ; conductivity Meter DDS-307 Determination of the blank microemulsion and between nisoldipine microemulsion conductivity ; the transmission electron microscope (TEM) investigated under microemulsion morphology , particle size and distribution of the sample was measured light scattering caliper .

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