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Objective: Acute lung injury ( acute lung injury , ALI) / acute respiratory distress syndrome (acute respiratory distress syndrome, ARDS) is the lead outside of cardiogenic pulmonary various internal and external pathogenic factors of acute hypoxic respiratory failure. ALI / ARDS has the same nature , but to varying degrees pathophysiological changes , the final stage of severe ALI or ALI is defined as ARDS . The cause of ALI / ARDS is complex , there are more than 100 kinds of diseases can be complicated by ARDS . Be clinically divided into the the lungs derived ARDS and lung exogenous ARDS . The former include : lung infection , aspiration of gastric contents , inhalation of toxic gases ; latter include : sepsis , shock , serious chest trauma and severe pancreatitis . More common in the most common form of clinical endotoxin sepsis damage ( about 40 %) , followed by gastric contents aspiration from ALI / ARDS , accounting for about 30% . Therefore, the experimental study of ALI / ARDS use of both cause damage model is consistent with the clinical situation . The glucocorticoids (glucocorticoids, GCs) endocrine hormone steroids with secreted by the adrenal cortex bundle , important physiological role . Clinical , GCs is more common medication for the treatment of ALI / ARDS . Theory , GCs inhibit the inflammatory response to mitigate the damage of the lung tissue cytokines and inhibit fibrosis and other effects , it is used in the treatment of ALI / ARDS received very good results , but that is not the case . For a long time , GCs in ALI / ARDS is always mixed . However , in clinical practice , always seem to benefit from glucocorticoid treatment , so the GCs of ALI / ARDS
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