Dissertation > Excellent graduate degree dissertation topics show

Study of Dynamic Changes of Serum Soluble Intercellular Adhesion Molecule-1 and Relation with Aggregation of Erythrocyte in Type 2 Diabetic Rats

Author: WangLiNa
Tutor: ZhouHuiMin
School: Hebei Medical University
Course: Internal Medicine
Keywords: Type 2 diabetes mellitus Animal models Intercellular adhesion molecule-1 Erythrocyte aggregation index Whole blood viscosity Fasting glucose
CLC: R587.1
Type: Master's thesis
Year: 2006
Downloads: 64
Quote: 0
Read: Download Dissertation

Abstract


Objective: In recent years, the incidence of type 2 diabetes increasing , the main factor affecting the prognosis of patients in its chronic complications occur sooner or later, its severity , with the deepening of the study , the role of adhesion molecules in its process more and more important for people . Studies have shown that ICAM-1 expression in vascular endothelial cells in diabetic microangiopathy increase mediated leukocyte adhesion to vascular endothelial cells , induced by a series of immune and inflammatory response , blocking capillaries ; promote atherosclerotic macrovascular complications occurred in turn give rise to the development of cardiovascular and cerebrovascular diseases . Exist in human serum soluble intercellular adhesion molecule -1 (sICAM-1) , was positively correlated with the inflammatory response , which comes mainly from the ICAM-1 lysis way through the cell membrane shedding or cell necrosis may ICAM-1 mRNA different splice forms differentially expressed protein directly into the blood formed soluble form of ICAM-1 levels may indirectly reflect the determination of simple , with a high clinical value . Another feature of diabetic humans exist in a series of pathological changes in red blood cell aggregation , microcirculation caused . SICAM- 1 and erythrocyte aggregation between is not necessarily associated with it ? Has been reported so far has not . This study is the first preparation of type 2 diabetic rat model , 12, 16 weeks of sICAM-1 concentration in the detection of its touch , observe the dynamic changes ; same period fasting blood glucose , blood rheology each indicators ( primarily red blood cell aggregation index and low shear rate under the whole blood viscosity ) to understand the diabetic rat sICAM-1 changes in trends , with the progress of the disease and to explore its relationship with erythrocyte aggregation , for early clinical detection, treatment complications provide an objective basis .

Related Dissertations

  1. Relationship between Level of Serum Uric Acid and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  2. Efficacy and Safety of Biphasic Insulin Aspart 30 Once-daily Treatment in Patients with Type 2 Diabetes,R587.1
  3. The Blood Glucose Control and Influencing Factors in Type 2 Diabetic Patients with Oral Hypoglycemic Agents,R587.1
  4. Experimental Study of Neural Stem Cells around the Lateral Ventricular Zone of the Hydrocephalus Rats,R742.7
  5. Association of Genetic Variation of UTS2 Gene with Type2 Diabetes Mellitus and Hypertension,R587.1
  6. Effect of Gastric Bypass on the Blood Glucose Level in Type 2 Diabetes Rat Model,R587.1
  7. Relationship between Postprandial Blood Pressure and Lower Extremity Arterial Disease in Patients with Type 2 Diabetes Mellitus,R587.1
  8. The Expression Mechanism of Calmodulin in Rat with Brain Contusion,R651.1
  9. Establishment of Subcutaneous Transplanted Tumor Model of Skin Adenocarcinoma in Balb/c Mice,R739.5
  10. The Comparison of Therapeutic Effect and Security between CSⅡ and MDI in Type 2 Diabetes Mellitus,R587.1
  11. The Characteristics of Coronary Angiography in Type 2 Diabetes Mellitus Patients with Suspected Coronary Artery Disease,R587.1
  12. Effect of Whey Protein on Improving Insulin Resistance and the Underlying Mechanisms,R587.1
  13. The Changes of T Lymphocyte Subsets and Costimulatory Molecules Before and After Shuxuetong Treatment in Type 2 Diabetes Subjects with Diabetic Kidney Disease,R692
  14. 50 Cases of Type 2 Diabetic Patients Serum Trace Element and Vitamin Change Analysis,R587.1
  15. Correlation Studies of Plasma Fatty Acids and Type 2 Diabetes Mellitus: Case Control Study,R587.1
  16. Cytokines in C57BL/6 Mice Model of Hepatitis B Virus Infection,R512.62
  17. Transplantation of Umbilical Cord Mesenchymal Stem Cells into Cisterna Magna for Cerebral Hypoxic-ischemic Rat Model,R722.1
  18. Effects of Rem Sleep Deprivation on CRF and CRF Receptors mRNA in Depressive Rats’ Medulla Oblongata、hippocampus and Hypothalamus Treated with Chronic Stress,R749.4
  19. Experimental Study of Th17 Related Factors of Animal Models Infected with Mycoplasma Suis,S858.28
  20. Effects of Lidocaine on Liver Injury Induced by Intestinal Ischemia-Reperfusion in Young Rats,R965
  21. Experiment Study of Low-level Semiconductor Laser Therapy to Oral Ulcer,R781.5

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
© 2012 www.DissertationTopic.Net  Mobile