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Objective: facial miliary lupus (Lupus Miliaris Faciei, LMF) is a chronic inflammatory skin disease , its etiology and pathogenesis is not clear . Diameter of 1 ~ 3mm, yellow to brownish-red or brown smooth surface hemispherical or dome-shaped papules ( sometimes accompanied by shallow scar ) , isolated or fusion , the clinical features often occurs in young people , male and female disease . Slide pressure attending law shows applesauce color nodule . Healed with atrophic scars , often have a great impact to the patients physical and mental health . Its histopathological tuberculoid infiltration, sometimes visible caseous necrosis , it was originally considered to be a variant of tuberculous lupus or tuberculosis rash , scholars LMF pathogenesis of Mycobacterium tuberculosis' dissertation">Mycobacterium tuberculosis is still controversial . To Mycobacterium tuberculosis DNA was detected in the LMF the skin lesions secretions or paraffin-embedded specimens , but some people could not be detected ; been proposed LMF is the emergence of an allergic reaction due to the diffusion of the deep tuberculosis ; There think LMF is a foreign body granuloma, granulomatous rosacea ; Others study LMF immune abnormalities was detected the LMF lesions of IFN- γ , lysozyme levels , serum levels of IL - 2 and TNF -α levels . But for Mycobacterium tuberculosis role in the pathogenesis of inconclusive cyclooxygenase -2 ( Cox -2 ) , CD68 's role in its pathogenesis has not been reported . Cyclooxygenase (Cox) , the prostaglandin ( PG ) synthesis , the initial steps of the key rate limiting enzyme in the metabolism of arachidonic acid into various PGs product , so as to maintain a variety of pathophysiological process . Cox-2 expression was induced physiological circumstances , most organizations no expression , but can be induced by inflammatory mediators, cytokines , tumor promoters , etc. , in the inflamed tissues or tumors overexpressed . CD68 is mainly expressed in macrophages , and the surface of the tissue cells , involved in cell immunity , as well as by the immune-mediated
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