Dissertation > Excellent graduate degree dissertation topics show

The Effect of Vitamin D on Insulin Resistance and Dyslipidemia of Patients with Peritoneal Dialysis

Author: JiaZuo
Tutor: ShiYongBing
School: Suzhou University
Course: Internal Medicine
Keywords: Peritoneal dialysis vitamin D 25(OH)D insulin resistance dyslipidemia
CLC: R459.5
Type: Master's thesis
Year: 2011
Downloads: 39
Quote: 0
Read: Download Dissertation

Abstract


Objective:To observe the level of 25 hydroxyl-vitamin D(25(OH)D) of Patients with peritoneal dialysis and the correlation between 25(OH)D and HOMA-IR to analysis the effect of 25(OH)D on insulin resistance of patients with peritoneal dialysis;Observe the relation between 25(OH)D and triglyceride(TG)、total cholesterol(CHOL).To demonstrate the relation between 25(OH)D and dyslipidemia of patients with peritoneal dialysis.Methods:Fifty Patients who undergone Peritoneal dialysis for more than three months and twenty-one healthy persons were selected and diabetes、received vitamin D or analogues or lipid-lowering drugs、acute infections、serious heart failure and trauma were excluded. 25(OH)D were measured by enzyme-linkd immunosorbent assay(ELISA) as a index of vitamin D state. Glycosylated hemoglobin(HBA1C)、fasting plasma insulin(Fins)、fasting plasma glucose(FPG)、total cholesterol(CHOL)、triglycerides(TG)、low density lipoprotein (LDL)、serum albumin(ALB)、serum creatinine(Scr)、serum phosphate(P)、parathyroid hormone(PTH) were measured during the corresponding time.Insulin resistance was evaluated by the homeostasis model assessment method (HOMA).Vitamin D deficiency was defined if 25(OH)D level are less or equal to 50nmol/L.Compare the level of 25(OH)D between peritoneal dialysis and health group,and analysis the effect of Vitamin D level on insulin resistance and dyslipidemia.Result:1. 25(OH)D level of peritoneal dialysis group was obviously lower than that of health group(P<0.01), HOMA-IR、Fins of Peritoneal dialysis group was obviously higher than that of health group(P<0.01). 25(OH)D level was negatively correlated with HOMA-IR、HbA1C、Fins(P<0.01).The level of HOMA-IR、HbA1C、Fins in group A were significantly higher than that of group B(P<0.01). 2.The TG、VLDL which represent dyslipidemia in peritoneal dialysis group were significantly higher than that of health group,HDL in peritoneal dialysis group were significantly lower than that of health group(P<0.01). 25(OH)D level was obviously positively correlated with HDL,was obviously negatively correlated with VLDL(P<0.01), was negatively correlated with TG(P<0.05). The level of TG、VLDL in group A were significantly higher than that of group B(P<0.01).However the level of HDL in group A were significantly lower than that of group B(P<0.01).Conclusion:1. Insulin resistance and hypovitaminoisis D is existed in most patients with peritoneal dialysis.Vitamin D level was compactly correlated with insulin resistance,and significantly affects glycometabolism.2. Dyslipidemia is existed in patients with peritoneal dialysis to some extent.The level of vitamin D is a important factor correlated with dyslipidemia.Whether improve hypovitaminoisis D is a way to regulate glycometabolism and lipid metabolism need to further study.

Related Dissertations

  1. Study on Relationship between Endothelin-1, Insulin Resistance and Acute Ischemic Cerebrovascular Disease,R743.3
  2. Studies on the Formation and Control of Volatile N-Nitrosamines in Dry-Cured Meat,TS251.51
  3. The Influence of Early Intervention of Vitamina Combined with Mycobacterium Bovis Bacillus Calmette-Guerin on Lung CD11C+ and Anti-OVA Special IgE Expression in Adult SD Mice Asthma Model,R562.25
  4. The Influence in Different Route of Medication with Vitamin A on CD4~+CD25~+ Regulatory T Cell and Cell Factor of IL-4、 IFN-γ in a Rat Persistent Asthma Model,R562.25
  5. Effects of Vitamin A and Montelukast on Airway Inflammatory Cells and Th1/Th2 Balance in Mouse Model of Asthma,R725.6
  6. QTL Maping and Gnenetic Analysis of Amino Acids and Vitamin C Content in Soybean Sprouts,S649
  7. Expression and Significance of HIF-1α on the Insulin Resistance during the Injury of Reperfusion of Ischemic Myocardium in Dog Undergoing Cardiopulmonary Bypass,R654.1
  8. Resuscitative Time and Vitamin C on Epithelial Cell Apoptosis of Skin Hair Follicle Partial Thickness Burn in Rats,R644
  9. Shamisen Medicinal and Edible Herbs on glucose and lipid metabolism in the metabolic syndrome and antioxidant effects,R285.5
  10. Myocardial infarction in young men the clinical features and prognosis of dyslipidemia with recent mid-term clinical studies,R542.22
  11. PPARa gene V227A polymorphism with early -onset type 2 diabetes Correlation,R587.1
  12. Study on Cytotoxicity, DNA Damage and Repair Induced by Phenol in Vitro,R114
  13. Studies on Magnetic Nanocomposite Particles as Drug Carriers for Photodynamic Therapy Agents,TB383.1
  14. Density Functional Theory Calculation on Principle Vitamin Eliminating Free Radicals,TS201
  15. The Mechanism of Lethal Effect of High-dose Vitamin C on Renal Cancer Cells,R737.11
  16. The Association of ApoB and ApoAI Gene Polymorphism with Dyslipidemia in Han Chinese of Xinjiang Shihezi,R589.2
  17. Protective Effects of Vitamin C on Alcoholic Brain and Liver Damages in Rats,R965
  18. Study of Health Care and the Intervention of Vitamin C on Workers Exposed to Dimethylformamide,R131
  19. Porous Hydroxyapatite Nanoparticle as a Controlled Release Carrier of Skeletal-related Drugs,R943
  20. 50 Cases of Type 2 Diabetic Patients Serum Trace Element and Vitamin Change Analysis,R587.1
  21. The Effect of Vitamin E and Selenium on Apoptosis and Oxidative Damage of Human Thyrocyte Induced by H2O2,R581

CLC: > Medicine, health > Clinical > Therapy > Dialysis therapy
© 2012 www.DissertationTopic.Net  Mobile