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Sheep sheep during late pregnancy toxemia of pregnancy is due to the body of carbohydrates and volatile fatty acid metabolic disorders caused by a systemic dysfunction subacute metabolic diseases. The main clinical manifestations of hypoglycemia, blood ketone, ketone urine, outliers, anorexia, ataxia, numbness, and finally death. For a better understanding of sheep toxemia of pregnancy, toxemia of pregnancy present study sheep pathological model of replication, histological observation, serum (liquid) and mitochondrial biochemical indicators will be measured, the following conclusions: Pregnancy Final sheep in restricted movement, restricted feeding, stress in the case of sheep can successfully replicate the pathological model of toxemia of pregnancy. Sheep suffering from toxemia of pregnancy, resulting in a large number of toxic substances - ketone bodies, tissues and organs of the body produce toxic effects. Lack of sugar in the body and because Bing Yang, tissue energy supply shortage, resulting in various tissues and organs capillary congestion, edema, hemorrhage; epithelial cell degeneration and necrosis; neurons form nerve cells macrophages phenomenon, Nissl bodies reduced protrusion disappeared or broken, Some neurons in the nucleus dissolved and disappeared, brain parenchyma vacuoles, liver, kidney cells, mitochondria vacuolation, increased glycogen granules in the cytoplasm; fat metabolism disorder caused by fatty liver changes. Sheep suffering from pregnancy toxemia, malate dehydrogenase activity and mitochondrial aspartate aminotransferase activity decreased and pyruvate content decreased, so that the body generates oxaloacetate reduction caused by β-oxidation of fatty acids, acetyl coenzyme A into citric acid cycle and ketone utilization disorder occurring disorders. Liver mitochondrial glycerol phosphate dehydrogenase activity was significantly decreased, so that glycerol as precursors gluconeogenesis metabolic process is restricted, unable to meet the body's use of sugar. Sheep, toxemia of pregnancy, the liver mitochondrial glycerol phosphate dehydrogenase activity (r = 0.861, p lt; 0.05) and serum malate dehydrogenase activity (r = 0.736, p lt; 0.01) and four iodine gland of the original acid correlated, suggesting that four iodine THYRONINE with sheep toxemia of pregnancy have a certain relationship. Through this trial histopathology and biochemical measurement results, combined with results of previous studies, can be inferred: When the ewe can not get from diet and sufficient energy reserves, while the mother in order to meet their own and sustain fetal growth development needs, the utilization of body fat while constantly replenish their energy. Because lipoprotein generation process, the process of fatty acids into the citric acid cycle, ketone bodies utilization process, glycerol as precursors barriers to the process of gluconeogenesis, fatty fat decomposition process can only be generated along the ketone bodies, resulting in excessive formation of ketone bodies, causing a series of pathological changes.
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