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Purpose by observing qiju capsule on blood pressure in spontaneously hypertensive rats (SHR), left ventricular weight to body weight ratio (LVW / BW), myocardial intracellular calcium concentration ([Ca 2 ] i ) and myocardial tissue proto-oncogene c-myc mRNA expression, and to explore the role of the party left ventricular hypertrophy and its mechanism, provided the experimental basis for the further development and clinical application. Method SHR 32 rats were randomly divided into qiju capsule group (A, 8), benazepril group (B, 8), qiju capsules plus benazepril group (C, 8), model group ( group D, 8), and then take the eight normal SD rats as normal control group (E, 8), for a total of five groups. Each treatment group was given the corresponding dose gavage normal group and model group at the same time give the same amount of distilled water, once a day, 12 weeks of treatment, weekly measurement of blood pressure, blood pressure fluctuations curves, and observed the general. Specimens are collected at the end of the experiment, the detection of left ventricular weight to body weight ratio (LVW / BW), myocardial [Ca 2 ] i and myocardial tissue proto-oncogene c-myc mRNA expression, and the application of the microscope myocardial microstructure. All the data were statistically using SPSS 11.5 for Windows. Results qiju capsules can reduce the blood pressure of SHR, left ventricular mass, myocardial [Ca 2 ] i and the expression of c-myc mRNA in myocardial tissue (P lt; 0.05), and stable myocardial micro structure. Qiju capsules with benzene enalapril compared to improve the general situation is better, left ventricular mass, c-myc mRNA expression and benazepril no significant difference (P gt; 0.05), myocardial microstructure two by similar; qiju is capsule the buck strength and reduce the of of Ca 2 , role not as benzene that Plymouth (P lt; 0.05). Three treatment groups to Capsule and, qiju, benazepril best effect, and benazepril compared reduce the myocardium [Ca 2 , role excellent on the latter (P LT; 0.05), and the remaining indicators although no significant difference, but there is still a certain trend in the microstructure to improve the general condition and stabilize the myocardium than benazepril. Conclusion (1) qiju capsule can effectively prevent left ventricular hypertrophy. (2) qiju Capsules for Prevention and left ventricular hypertrophy mechanism may be related to lower blood pressure, reduce the intracellular calcium ion concentration and suppression
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