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The Study for the Relationship between C-664G Polymorphism of Human Atrial Natriuretic Peptide Gene and the Hypertension in Xinjiang Kazakans

Author: ChangGuiJuan
Tutor: ZhangXiangYang;LiNanFang
School: Xinjiang Medical University
Course: Of Cardiovascular
Keywords: Hypertension ANP Gene polymorphism Kazakh
CLC: R544.1
Type: Master's thesis
Year: 2005
Downloads: 34
Quote: 0
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Abstract


Objective: To study the human atrial natriuretic peptide (hANP) gene C-664G in the Kazakh population variation exists , the variation is associated with essential hypertension in Kazaks (EH) is relevant . Methods: Using polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP), 260 cases in Xinjiang Kazakh patients with EH (EH group ) and 169 cases of normal blood pressure (NT group ) in the peripheral blood leukocyte DNA, for hANP gene C-664G polymorphism detection , observation CC, GG and CG genotypes , and this locus C, G allele frequencies in different EH group and NT group distribution . Results : (1) CC, CG and GG genotype frequency distribution in EH group was 0.99, 0.01 and 0 , in the NT group was 0.99, 0.01 and 0 , the difference between two groups was not significant (P gt; 0.05); C and G allele frequencies in the EH group were 0.99,0.01, NT group were 0.997 and 0.003 , the difference between two groups was not significant (P gt; 0.05). ( 2 ) comparing gender groups found CG, are located in the Kazakh female group , female EH group CG genotype frequency ( 0.02 ) and G allele frequency ( 0.01 ) were higher than the NT group CG genotype frequency ( 0.01 ) and G , etc. allele frequency ( 0.005 ) , the difference between two groups was not significant (P gt; 0.05). Conclusions : (1) hANP gene C-664G in the Kazakh population variation exists in the variation and essential hypertension in Kazaks no correlation . (2) hANP gene C-664G mutation in the Kazakh population trends in gender differences that may exist .

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
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