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The Change of Hearing P300 and the Mismatch Negativity in the Newly Parkinson’s Disease Patient Around Treatment and the Correlatead Research

Author: ZhangDengYu
Tutor: XueShouRu；WangHongXia
School: Suzhou University
Course: Neurology
Keywords: Parkinson’s disease P300 MMN Around the treatment MMSE
CLC: R742.5
Type: Master's thesis
Year: 2011
Downloads: 40
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Abstract


ObjectiveThis research’s goal is to compares the diagnosis value of event related potential P300 to that of the mismatch negative (MMN) wave in the newly no-treatment Parkinson’s disease patient with mild cognitive impairment. And analysize the change of two kinds of electric potential ingredient Around anti-Parkinson pharmacological treatment.Methodsmeasuring early time nondespondent-nonstupid Parkinson patient’s peak latency and the baseline-peak wave amplitude of P300 and MMN of 46 healthy examples(control group) and 40 patients (patient group) in the hearing Oddball pattern. two groups are matched in age﹑sex and the education level, and compare the peak latency and the baseline-peak wave amplitude of P300 and MMN of control group and patient group before treatment and 1 year later respectively.Results1)Comparing with the normal control group, the patient group’s P300 latency (368.82±35.94) are significantly longer than the control group, P﹤0.05, of which 20 examples are abnormal, the rate of abnormality is 50%; The amplitude(6.62±1.52) than the control group decreased, P>0.05, no statistically significant difference. 2) the patient group’s MMN latency (213.25±18.41)are very significantly longer than the control group, P﹤0.01, of which 27 examples are abnormal, the rate of abnormality is 67.5%; The amplitude(2.65±0.39) than the control group decreased, P>0.05,no statistically significant difference. 3) after pharmacological treatment, the MMN latency (197.84±12.4) reduce obviously, P﹤0.05, the difference has statistical significance; The P300 latency (359.49±35.01) reduces not obvious, P>0.05, no statistically significant difference 4)comparing MMN latency(191.09±11.68)with N2 latency(202.15±12.29), P﹤0.05, the difference has statistical significance; 5)Around the patient group treatments the MMSE grading is(26.50±2.76)scores and(27.08±2.02)respectively, P>0.05, no statistically significant differenceconclusion1) the P300 and MMN latency obvious longer than control group especially the MMN latency, the MMN has higher abnormality rate. MMN as the quantification electrophysiology, can response mild cognitive impairment of early time Parkinson’s disease patient more sensitive than P300. 2) the obvious decreased MMN latency is more meaningful than decreased p300 latency after the treatment,therefore,improvement of electrophysiology MMN respongding to mild cognitive impairment play an important guiding role to the clinical medicine curative effect appraisal, the medicine diagnosis treatment and the instruction of clinical medication. 3) MMN as an endocardial ingredient, is different with the N2 wave, and occurs before N2. 4) MMSE as a neuropsychology examination has a no distinct improvement before and after treatment. its sensitivity is inferior to MMN, which manifests limitation of MMSE in the appraisaing slight change of cognition function. The experiment need to unifies more neuropsychology marking scales, including Parkinson special-purpose cognition marking scales.

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