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Expression and Effects of TGF-β1 and Its Intracellular Signaling Molecule Smad4, Smad7 in Human Glioma

Author: ShaoBuYun
Tutor: ChenQianXue
School: Wuhan University
Course: Surgery
Keywords: Glioma Transforming growth factor--β1 Smad4 Smad7
CLC: R739.4
Type: Master's thesis
Year: 2005
Downloads: 118
Quote: 0
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Abstract


Objective To investigate the expression of TGF-β1 and its intracellular signaling molecules Smad4, Smad7 in human glioma.Methods The expression levels of Smad4 and Smad7 in 30 cases of human glioma and 8 cases of normal brain tissue specimen were detected by immunohistochemical technics.Results In normal brain tissue, grade Ⅰ Ⅱ and ⅢⅣ astrocytoma, the positive expression level of TGF-pi was 5.90±3.78, 14.21±4.89, 36.02±12.33 respectively, and the level of Smad4 was 44.80±16.19, 25.81±9.48, 6.73±3.71 respectively, and the level of Smad7 was 6.69±3.86, 18.22±7.84, 41.95±17.27 respectively. The difference was significant （P<0.05） among normal brain tissue, group Ⅰ Ⅱ and Ⅲ-Ⅳ. The expression of Smad4 was lower in glioma than that in normal tissue. However, the expression of Smad7 and TGF--β1 was positively correlated with the tumor grade. There was a positive correlation between TGF--β1 and Smad7, while a negative correlation between TGF-pi and Smad4.Conclusion These findings suggested that TGF--β1 and Smad7 play an important role during the malignant behavior of glioma. Smad4 could be a candidate tumor suppressor gene of glioma.

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