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Preparation and Characterization of Magnetic Polylactic Acid Microspheres

Author: MaoShuFang
Tutor: ChenXiaoMing
School: Wuhan University of Technology
Course: Biomedical Engineering
Keywords: Magnetic microspheres Polylactic acid Fe3O4 Magnetic particles Solvent extraction evaporation method
CLC: R318.08
Type: Master's thesis
Year: 2006
Downloads: 252
Quote: 1
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Abstract


Magnetic microspheres has a very wide range of applications in biomedicine, magnetic microspheres coated on the surface of polymer materials commonly used amino acid polymer or poly polysaccharide material, polylactic acid as a covering material applied research reports less. The purpose of this study is to attempt to examine the skeleton material coated magnetic microspheres polylactic acid as focused on their preparation process and the impact parameter. First, the paper to FeCl 2 · 4H 2 O the FeCl 3 · 4H 2 O as raw material, the use of The chemical coprecipitation prepared nanoscale Fe 3 O 4 magnetic particles; NH 3 · H 2 O as the precipitating agent for adjusting the pH value in the experiment. Investigated through a series of experiments solution molysite solution concentration change, the amount of alkali reaction Fe 3 : the Fe 2 ratio and crystallization temperature change generate the fe 3 O 4 magnetic particle performance; them by means of XRD, SEM analysis test means characterized. The experimental results show that: the prepared Fe of 3 O 4 magnetic particles were spherical particle size of about 16nm, superparamagnetic, to meet the core / shell magnetic polymer The microspheres as the requirements of the magnetic material. Secondly, in using polyethylene glycol 4000, sodium dodecyl sulfate (SDS) and sodium oleate, three surface active agents as the basis of a comparative study on the effective selection of sodium oleate as a modifier Fe < sub> 3 O 4 surface modification of the magnetic particles. XRD, TEM analysis method performance characterization. The results show that: the sodium oleate, oleic acid ions generated at the particle surface by physical adsorption and chemical adsorption of a dense layer of the cladding layer; After surface modified Fe 3 O 4 < / sub> the settling time of the magnetic particles greatly extended, ζ potential determination of the absolute value is greater than 30mV, to stabilize the dispersion system. Good coating effect of the resultant magnetic particles, the particle size distribution, good dispersibility and surface oleophilic, a magnetic material can be used as targeted drug delivery. Finally, using the solvent evaporation method was extracted successfully prepared magnetic microspheres of polylactic acid, with dichloromethane as the organic solvent, polyvinyl alcohol as emulsifier. Examines the size of the molecular weight of the polylactic acid, polylactic acid added in an amount, and the proportion of the added amount, the organic solvent is added in an amount and ratio on the performance of the generated magnetic microspheres of polylactic acid and magnetic particles; analyzed the use of other means of TGA, SEM , Characterization. The results show that: the magnetic particle size of the microspheres of polylactic acid in 20 ~ 30μm, the high magnetic content of 38.7% to 47.6%, the magnetic microspheres are substantially spherical and good dispersibility. Entrapped drugs; the same time as the polymer of polylactic acid with a variety of reactive functional groups can also be connected to the surface of the microspheres having a biologically active substances, such as drugs, immune proteins, and so on. Can be safely and effectively used for targeted drug delivery, gene therapy.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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