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Sucralose (Sucralose) is a new strong sweet ignorance agent , its chemical name is 4,1 ', 6'-trichloro- -4,1 ', 6'- trideoxy galacto sucrose . High sweetness of the sweetener , pure sweetness , good chemical stability , non-toxic side effects in the human body is almost absorbed heat value of zero , the excellent sweetness alternatives is diabetic and obese patients . Route of synthesis of sucralose Law on the Protection of the full group , the monoester and enzyme produced today sucralose most manufacturers to adopt the Law on the Protection of the whole group . In this paper, the existing the sucralose full group protection improved synthetic route . First, the use of sucrose in N-methyl morpholine and N , N - dimethyl formamide mixed solvent with triphenylchloromethane reaction on eight hydroxyl protected sucrose , and then acetylated by acetic anhydride , and then in the hydrogen chloride gas the role trityl off and recovered triphenylchloromethane , and then with methyl isobutyl ketone as reaction medium, in the acetyl migration reaction occurs under the action of acetic acid , and then used in the toluene system triphenylphosphine oxide and thionyl chloride chloro- substituted 1 ', 6' , 4 hydroxyl groups , recovery of triphenylphosphine oxide , and finally deacetylated in methanol and sodium methoxide system obtained 4,1 ' , 6'-trichloro - 4,1 ', 6'- trideoxy - galacto sucrose ( sucralose ) , with a total yield of 21.77% . The ratio of materials, reaction time, temperature , ventilation , speed and other factors influence on the reaction . The route process is simple, easy recovery of expensive raw materials , low cost , industrialization prospects .
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