Dissertation > Excellent graduate degree dissertation topics show

Study the Effects of Nerve Growth Factor on Angiogenesis of Regenerative Peripheral Nerve and Its Mechanisms

Author: ZhangYuBo
Tutor: WuYaMin
School: Third Military Medical University
Course: Surgery
Keywords: nerve growth factor vascular endothelial cell growth factor endothelial cells angiogenesis Von Willebrand Factor rat
CLC: R651.3
Type: Master's thesis
Year: 2005
Downloads: 141
Quote: 0
Read: Download Dissertation

Abstract


It is very important to supply blood for regenerative peripheral nerve. Degenerative, disintegrating axons and myelin sheath debris can be cleared out rapidly by the fairly rich blood-supplying, and secondary inflammation injury can also be relieved. At the same time, nutrimental materials can be provided for schwann’s cells (SCs), which increases biological function of the SCs; rebuilding microenvironment is favourable to regeneration of axons. So blood-supplying not only can induce regeneration of the injured axons, but also can induce reformation of the myelin sheaths, facilitating growth and matureness of the regenerative nerve fibres, promoting recovering nerve function. Blood-surpplying is more required to repair thick or long peripheral nerve defects than thin or short ones. Many methods have been used to repair peripheral nerve defects, such as nerve grafting with blood vessels, implantation of an adventitia tube containing nerve segment and blood vessels, implantation of an adventitia tube with blood vessels and schwann’s cells, and so on. All of these methods have not evident effect for peripheral nerve regeneration and functional recovery. How to ameliorate the blood-supplying in course of the regeneration and repair of the injured peripheral nerve causes extensive interesting of neuroscience researcher. NGF is a neurotrophic factor that has been studied earlier and deeply, can promote growth of the nerve, maintain living of neurons and repair injured nerves. Recently It has been found out that NGF can promote angiogenesis of the non-neural peripheral tissue indirectly through increasing the expression of VEGF. Even NGF is called a vessel growth factor for that it can promote angiogenesis itself directly. NGF shows angiogenesis in non-neural peripheral tissue, such as ischemia muscle tissues, cornea, choroidal and iris etc. NGF’s angiogenesis on regenerative peripheral nerve is rarely reported.We initially observed more blood vessles in the regenerative nerve when we compared the different effects of NGF and CNTF in the process of their promoting nerve regenration, but is it sure to increase the quantity of blood vessels in the regenerative nerve? has NGF a

Related Dissertations

  1. Effects of Angiogenic Factor on Follicular Angiogenesis and Development in Immature Mouse,S865.13
  2. The Effect of Tanshinone ⅡA and Niacin on the Cardiovascular Function of Infant Obese Rat,R285.5
  3. Therapeutical Effects of Diammonium Glycyrrhizinate Lipid Ligand on Nonalcoholic Steatohepatitis and Its Partly Mechanisms of Action,R575.5
  4. Tissue-engineered Construction and Preliminary Implantation Study of Diamond-like Carbon Films for Artificial Mechanical Valve Applications,R654.2
  5. Dynamic Effect of Cold Restraint Stress on Damage of Ultrastructure and Expression of Heat Shock Protein in Rat Tissues,S858.91
  6. The Impact That Microwave Acted on the Function Recovery of Peripheral Nerve Injured Experimental Rat,R651.3
  7. Effect of β-elemene Combined with Radiotherapy on the Angiogenesis of Lung Adenocarcinoma Xenograft Tumor in Nude Mice,R734.2
  8. Experiment Study of Ethylhexyl Phthalate (DEHP) and It’s Metabol-ites (Single-ethylhexyl Phthalate, MEHP) Influencingon Sper Matogoniain Young Male Wistar Rats,R329
  9. Inhibition of Conventional Chemotherapy Combined with Metronomic Chemotherapy on Breast Cancer Xenografts in Nude Mice,R737.9
  10. Study on the Cell Cycle of Liver Cells during Rat Liver Regeneration,Q253
  11. The Regulatory Role of Proliferation and Apoptosis of ERK1/2 and JNK Signaling Pathways in Eight Liver Cell Types during Rat Liver Regeneration,Q418
  12. Clinical Efficacy Observation with Fu-Zheng-Gu-Ben on Septic Acute Deficiency Syndrome Patients,R278
  13. Effects of Angiopoietin-1 on Intercellular Junctional Protein in Human Umbilical Vein Endothelial Cells Cultured with High Glucose,R363
  14. BMP2 and VEGF165 Genes Transfected Rat Bone Marrow Mesechymal Stem Cells Simultaneity Expression,R329
  15. Effects of High-salt Dieet on Blood Pressure and the Remodeling of Carotid Arteries and the Intervention of Telmisartan in Wistar Rats,R544.1
  16. The Espression of C-reactive Protein in Rats of the Chronic Obstructive Pulmonary Disease with Diabetic,R563.9
  17. Relationship and Significance of Gene Transcription Profiles in Rat Liver Regeneration and Non-Alcoholic Fatty Liver Disease Occurrence,R575.5
  18. The Expression of Visfatin in Liver of Rats in Different Glucose Metabolic Statuses and Effects to Glucose and Energy Metabolism,R587.1
  19. The Beneficial Effects of Soy Isoflavones in Osteoporosis of Ovariectomized Rats,R580
  20. Morphological Characteristics of Brain Capillary Endothelial Cells and Neurons in a Ticellular System for Study on Neuroprotection and Neuroregeneration in Vitro,R651.1
  21. The Experimental Study of Antiangiogenic and Induction of Apoptosis by Maximum Tolerated Dose Combined with Low-dose Cyclophosphamide in Breast Cancer,R737.9

CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Peripheral nerve
© 2012 www.DissertationTopic.Net  Mobile