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The Influence of Different Intervention Factors on Permeabilities of Blood Vessels and Activities of ATPase of Organs in Rats during Hemorrhagic Shock and Suspended Animation

Author: ZhangWenKai
Tutor: YangTianDe
School: Third Military Medical University
Course: Anesthesiology
Keywords: suspended animation rat propofol organ MPO ATPase LD tissue permeability tissue water content hemorrhagic shock hypothermia resuscitation Morris water maze
CLC: R459.7
Type: Master's thesis
Year: 2005
Downloads: 42
Quote: 0
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Abstract


Background and objecbive: Standard cardiopulmonary-cerebral resuscitation fails to achieve restoration of spontaneous circulaton in ~50% of normovolemic sudden cardiac arrests outside hospitals and in essentially all victims of penetrating truncal trauma who exsanguinate rapidly to cardiac arrest. For such unresuscitable conditions, since 1984, Safar and Bellamy have recommended research into“suspended animation for delayed resuscitation.”This they have defined as“induction of preservation of the organism within the first 5 min of CA(no-flow) for transport and surgical hemostasis during clinical death, to be followed by delayed resuscitation to survival without brain damage”. The aim of this study was to explore the feasibility of applying technique relative to suspended animation to rehabilitating severe hemorrhagic shock in rats so that guidelines and references based on experiments could be available for resuscitating patient when needed.Methods: ExperimentⅠ, a total of 90 Wistar rats were randomly divided into 4 groups including sham operation group(S group), suspended animation group(SA group), suspended animation plus the dose of sedative concentration of propofol group(SA+S.P group) and suspended animation plus the dose of anesthetic concentration of propofol group(SA+A.P group). For S group,only femoral arterial catheter and femoral venous catheter were needed to be inserted .The models of suspended animation of 20℃in rats were established for the other three groups. The assaies of water contents, instant tissue permeabilities, the activities of myeloperoxidase(MPO)and ATPase as well as pathological results for brains, hearts, lungs, livers, kidneys, intestines and stomaches in each group were tested at the time point of 30min,60min and 90min respectively.ExperimentⅡ, a total of 22 Wistar rats were randomly divided into 4 groups including sham operation group(S group), shock plus rehabilitating with saline at normal temperature and maintaining temperature of anus (Ta) to baseline group(SH+NT group),

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